摘要
目的探讨血清白介素-2(IL-2)水平与卵巢储备功能减退(DOR)患者体外受精-胚胎移植(IVF-ET)妊娠结局的关系。方法选取2020年9月至2022年9月唐山市妇幼保健院收治的305例采用IVF-ET助孕的DOR患者作为观察组,选取本院同期305例正常健康孕妇作为对照组,观察组根据助孕结局分为妊娠组和未妊娠组。比较观察组和对照组血清IL-2水平,统计观察组妊娠结局,采用Logistic回归分析DOR患者IVF-ET治疗后妊娠失败的影响因素,绘制受试者工作特征(ROC)曲线分析各血清指标对DOR患者IVF-ET治疗后妊娠失败的预测价值。结果观察组血清IL-2水平高于对照组(P<0.05)。305例DOR患者妊娠成功率为53.11%(162/305)。未妊娠组移植前、后血清IL-2水平、窦卵泡计数<5发生率均高于妊娠组,血清抗米勒管激素(AMH)水平低于妊娠组(P<0.05)。窦卵泡计数少、血清AMH低表达、移植前血清IL-2高表达是DOR患者IVF-ET治疗后妊娠失败的影响因素(P<0.05)。血清AMH和移植前血清IL-2联合预测效能高于单独预测。结论血清IL-2水平与DOR患者IVF-ET妊娠结局密切相关,其或可成为临床预测DOR患者IVF-ET妊娠结局的辅助指标。
Objective To investigate the relationship between serum interleukin-2(IL-2)and pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)in patients with decreased ovarian reserve(DOR).Methods A total of 305 DOR patients who received IVF-ET assisted pregnancy at Tangshan Maternal and Child Health Hospital from September 2020 to September 2022 were selected as the observation group,and 305 healthy pregnant women admitted during the same period were included as the control group.The observation group were divided into pregnant group and nonpregnant group according to the outcomes of assisted pregnancy.The serum IL-2 levels of the observation group and the control group were compared,and the pregnancy outcome of the observation group was counted.Logistic regression was used to analyze the influencing factors of pregnancy failure after IVF-ET treatment in DOR patients,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of each serum index for pregnancy failure after IVF-ET treatment in DOR patients.Results The serum IL-2 levels in the observation group were higher than those in the control group(P<0.05).The pregnancy success rate of 305 DOR patients was 53.11%(162/305).The serum IL-2 levels and the incidence of antral follicle count<5 before and after transplantation in the non-pregnant group were higher than those in the pregnant group,while the serum anti-Müllerian hormone(AMH)levels were lower than those in the pregnant group(P<0.05).The low number of antral follicles,low expression of serum AMH,and high expression of serum IL-2 before transplantation were the influencing factors of pregnancy failure in DOR patients after IVF-ET treatment(P<0.05).The combined predictive efficacy of serum AMH and pre-transplant serum IL-2 was higher than each predictor alone.Conclusions Serum IL-2 level is closely related to the pregnancy outcomes of IVF-ET in DOR patients,and it may become an auxiliary indicator for clinical prediction of IVF-ET pregnancy outcomes in DOR patients.
作者
高商
宁艳春
姚雨宏
郭畅
丰程文
刘宝莲
GAO Shang;NING Yanchun;YAO Yuhong;GUO Chang;FENG Chengwen;LIU Baolian(Department of Reproductive Genetics,Tangshan Maternal and Child Health Hospital,Tangshan 063000,Hebei,China)
出处
《中国性科学》
2024年第10期69-73,共5页
Chinese Journal of Human Sexuality
基金
河北省医学科学研究课题计划项目(20231746)。
关键词
白介素-2
卵巢储备功能减退
体外受精-胚胎移植
妊娠结局
Interleukin-2
Decreased ovarian reserve
In vitro fertilization-embryo transfer
Pregnancy outcome
作者简介
通讯作者:宁艳春,E-mail:ningyanchun@163.com。
