摘要
目的探究腹腔镜前列腺癌根治术对局限性前列腺癌患者尿动力学及血清游离前列腺特异抗原百分率(FPSAR)的影响。方法选择局限性前列腺癌患者87例,随机数表法分为研究组与对照组。研究组患者44例给予腹腔镜前列腺癌根治术治疗;对照组患者43例给予开放性前列腺癌根治术治疗,观察2组术后国际前列腺症状评分(IPSS)、尿控率、尿动力学指标和FPSAR水平差异。结果术后,2组IPSS评分、膀胱顺应性(BC)、逼尿肌不稳定(DI)率、残余尿量(PVR)、前列腺特异抗原(t-PSA)、游离前列腺特异抗原(f-PSA)水平均降低,最大尿流率(Qmax)、最大尿流率时逼尿肌压力(Pdet at Qmax)、FPSAR均升高(P<0.05)。研究组IPSS评分、BC、DI、PVR水平均低于对照组,Qmax、Pdet at Qmax水平均高于对照组(P<0.05),2组t-PSA、f-PSA、FPSAR水平比较,差异无统计学意义(P>0.05)。研究组术后1个月、2个月、3个月、4个月尿控率均显著高于对照组(P<0.05)。结论腹腔镜前列腺癌根治术治疗局限性前列腺癌,可有效改善尿动力学指标,提高FPSAR水平,治疗效果较好。
Objective To investigate the effect of laparoscopic radical prostatectomy on urodynamics and serum free prostatespecific antigen ratio(FPSAR)in patients with localized prostate cancer.Methods A total of 87 patients with localized prostate cancer were selected and divided into the control group(n=43)and the study group(n=44)according to random number table method.The study group was treated with laparoscopic radical prostatectomy,and the control group was treated with open radical prostatectomy.The differences in postoperative International Prostate Symptom Score(IPSS),urinary control rate,urodynamic indexes levels and FPSAR between two groups were observed.Results After surgery,IPSS score,bladder compliance(BC),detrusor instability(DI)rate,post-voided volume residual(PVR),the levels of total prostate specific antigen(t-PSA)and free prostate-specific antigen(f-PSA)decreased in both groups,while maximum flow rate(Qmax),detrusor pressure at maximum urine flow(Pdet at Qmax),and FPSAR increased(P<0.05).The IPSS score,BC,DI rate,and PVR of the study group were lower than those of the control group,while the Qmax and Pdet at Qmax were higher than those of the control group(P<0.05).There were no statistically significant differences in t-PSA and f-PSA levels,and FPSAR between two groups(P>0.05).The urinary control rates of the study group were significantly higher than those of the control group at 1,2,3,and 4 months after surgery(P<0.05).Conclusion Laparoscopic radical prostatectomy can effectively improve the levels of urodynamic parameters,and increase FPSAR in the treatment of localized prostate cancer.This therapy has the good therapeutic effect.
作者
黄超
包伟
崔庆敖
成泽民
HUANG Chao;BAO Wei;CUI Qingao;CHENG Zemin(Dazhou Central Hospital,Dazhou 635000,China)
出处
《长春中医药大学学报》
2024年第10期1143-1146,共4页
Journal of Changchun University of Chinese Medicine
基金
四川省中医药管理局科学技术专项课题(2020LC0104)。
作者简介
黄超(1976-),男,主要从事泌尿系肿瘤,结石,尿控及男科疾病研究。
