摘要
目的探究免疫组化T淋巴细胞亚群分析对不稳定型心绞痛(UA)再发风险的影响。方法回顾性纳入2022年1月至2023年2月于盐城市中医院心血管内科住院治疗的UA患者96例以及非冠心病对照组患者75例。比较两组性别、年龄、糖尿病史、高血压病史,白细胞计数、淋巴细胞计数、中性粒细胞计数、空腹血糖、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇、甘油三酯、免疫组化T淋巴细胞亚群分析(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。同时行二项logistic回归分析UA发病的独立危险因素,最后采用ROC曲线分析得出CD4^(+)/CD8^(+)比值预测UA发病的最佳截点值。结果UA组年龄、是否患有高血压病、空腹血糖、高密度脂蛋白、低密度脂蛋白与对照组比较,差异有统计学意义(P<0.05);UA组患者各淋巴细胞亚群(CD4^(+)、CD8^(+)、CD3^(+)、CD4^(+)/CD8^(+))与对照组比较,差异均有统计学意义(P<0.05);logistic回归分析显示,年龄、CD4^(+)/CD8^(+)比值与UA患病独立相关(P<0.05);经ROC曲线分析CD4^(+)/CD8^(+)对UA患者斑块不稳定性预测的诊断价值,得出最佳截点值为2.915。结论外周血中T细胞亚群的变化可以削弱斑块的稳定性,导致并催化UA的发生发展。在UA患者中,CD4^(+)/CD8^(+)比值可能一个独立的评估预测因子。
Objective To explore the influence of immunohistochemical T lymphocyte subsets analysis on the recurrence risk of unstable angina(UA).Methods From January 2022 to February 2023,96 patients with UA and 75 patients without coronary heart disease(as the control group)who were hospitalized in the Department of Cardiology,Yancheng Traditional Chinese Medicine Hospital were included in this retrospective study.Gender,age,history of diabetes,history of hypertension,white blood cell count,lymphocyte count,neutrophil count,fasting blood glucose,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,triglyceride and immunohistochemical T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were compared between the two groups.Simultaneously,a binomial logistic regression analysis was conducted to identify independent risk factors for the onset of UA.Finally,the ROC curve analysis was used to determine the optimal cutoff value for predicting UA incidence using the CD4^(+)/CD8^(+)ratio.Results There was a statistically significant difference(P<0.05)in age,presence of hypertension,fasting blood glucose,highdensity lipoprotein,and low-density lipoprotein between the UA group and the control group.Compared with the control group,the lymphocyte subsets(CD4^(+),CD8^(+),CD3^(+),CD4^(+)/CD8^(+))of patients with UA showed statistically significant differences(P<0.05).Logistic regression analysis showed that age,CD4^(+)/CD8^(+)ratio,and UA were independently correlated(P<0.05).The diagnostic value of CD4^(+)/CD8^(+)in predicting plaque instability in patients with UA was analyzed by ROC curve analysis,and the optimal cutoff value was found to be 2.915.Conclusion The changes in T cell subsets in peripheral blood can weaken the stability of plaques,leading to and catalyzing the occurrence and development of UA.In patients with UA,the CD4^(+)/CD8^(+)ratio may be an independent predictive factor for evaluation.
作者
涂冬云
宋晓龙
伍德明
袁春玲
TU Dongyun;SONG Xiaolong;WU Deming;YUAN Chunling(Department of Cardiology,Yancheng Traditional Chinese Medicine Hospital,Jiangsu,Yancheng 224000,China)
出处
《中国医药科学》
2024年第18期131-134,171,共5页
China Medicine And Pharmacy
基金
江苏省老年健康科研项目(LKM2022076)
江苏省盐城市卫健委医学科研项目(YK2023066)。
作者简介
通讯作者:伍德明。
