摘要
鸦胆子是我国传统中药之一,其主要活性化学成分是苦木素类化合物,具有抗肿瘤、抗炎、抗病毒等药理作用。本文通过整理、归纳和分析现有的苦木素类化合物研究成果,探讨具有抗炎活性的化合物结构的异同及其作用机制。苦木素类化合物中的A环、C环和D环上的α,β-不饱和酮、糖基、烯键的取代能影响其抗炎活性。这些化合物主要通过调控细胞内信号传导通路NF-κB发挥抗炎作用,此外,它们还能抑制多种促炎因子的表达,包括TNF-α、IL-6、IL-β等,从而有效地抑制炎症反应。苦木素类化合物的抗炎活性可能与其抗补体活性相关,特别是与补体蛋白C3a和C5a有关。
Brucea javanica was one of the traditional Chinese medicines,and its main active chemical components were quassionoids,which had pharmacological properties such as anti-tumor,anti-inflammatory,and antiviral.This article collected,summarized,and analyzed existing research results on quassionoids compounds,to explore the mechanisms and the structural differences of compounds with anti-inflammatory activity.The substitution ofα,β-unsaturated ketones,glycosides,and olefinic bonds on the A,C,and D rings in quassionoids compounds could affect their anti-inflammatory activity.These quassionoids mainly exerted anti-inflammatory effects by regulating the intracellular NF-κB signaling pathway.In addition,they could also suppress the inflammatory response effectively by inhibiting the expression of various pro-inflammatory factors,including TNF-α,IL-6,IL-β,etc..The anti-inflammatory activity of quassionoids might be related to their anti-complement activity,particularly with complement proteins C3a and C5a.
作者
王文敏
吴佳辉
石凌钰
万阳
冯育林
温泉
陈道峰
Wang Wenmin;Wu Jiahui;Shi Lingyu;Wan Yang;Feng Yulin;Wen Quan;Chen Daofeng(Jiangxi University of Chinese Medicine,Nanchang 330004,China;National Pharmaceutical Engineering Center for Preparation of Chinese Herbal Medicine,Nanchang 330006,China;School of Pharmacy,Fudan University,Shanghai 201203,China)
出处
《中国野生植物资源》
CSCD
2024年第9期88-95,共8页
Chinese Wild Plant Resources
基金
江西省自然科学基金项目(20212ACB206007)
国家自然科学基金项目(81860684)
江西省教育厅项目(GJJ190689)。
关键词
鸦胆子
苦木素
结构
抗炎机制
Brucea javanica
Quassinoids
Structure
Anti-inflammatory mechanism
作者简介
王文敏(1999-),女,硕士研究生,研究方向为中药药效及作用机制。E-mail:1105323032@qq.com;通讯作者:温泉(1987-),男,博士,副教授,研究方向为中药药效物质基础。E-mail:qwen12@fudan.edu.cn;共同通讯作者:陈道峰(1965-),博士,教授,研究方向为中草药活性成分及其资源。E-mail:dfchen@shmu.edu.cn。
