摘要
目的探讨血清可溶性血管内皮生长因子受体1(soluble vascular endothelial growth factor receptor 1,sFlt-1)、可溶性血红蛋白清道夫受体163(soluble hemoglobin scavenger receptor 163,sCD163)在重症支原体肺炎(mycoplasma pneumonia,MPP)患者中的表达水平,分析其预测MPP预后的价值。方法选取2021年10月至2023年10月于齐齐哈尔市中医医院就诊的MPP患者249例(MPP组)作为研究对象,根据MPP患者病情严重程度,将患者分为轻症组145例与重症组104例,根据预后情况将104例重症组患者分为预后不良组30例与预后良好组74例。选取同期于本院体检健康者250例作为对照组。收集研究对象相关临床资料,酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)法检测血清sFlt-1、sCD163水平。多因素Logistic回归分析影响重症MPP患者预后的因素;受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析血清sFlt-1、sCD163对重症MPP患者预后的预测价值。结果MPP组患者血清sFlt-1、sCD163水平显著高于对照组(P<0.05)。重症组患者血清sFlt-1、sCD163水平显著高于轻症组(P<0.05)。预后不良组患者血清sFlt-1、sCD163、C反应蛋白(C reactive protein,CRP)水平显著高于预后良好组(P<0.05)。多因素Logistic回归分析结果显示,sFlt-1、sCD163是重症MPP患者发生预后不良的危险因素(P<0.05)。ROC曲线结果显示,血清sFlt-1、sCD163水平单独及联合预测重症MPP患者预后不良的AUC分别为0.846、0.854、0.923,且二者联合优于单独预测(Z=2.656、2.519,P<0.05)。结论血清sFlt-1、sCD163升高与重症MPP患者预后不良密切相关,且对患者预后不良有一定的预测价值。
Objective To investigate the expression levels of serum soluble vascular endothelial growth factor receptor 1(sFlt-1)and soluble hemoglobin scavenger receptor(sCD163)levels in patients with severe mycoplasma pneumonia(MPP),and to analyze their value in predicting the prognosis of MPP.Method A total of 249 MPP patients(MPP group)who visited our hospital from October 2021 to October 2023 were collected as the study subjects,according to the severity of MPP patients'condition,they were separated into a mild illness group of 145 cases and a severe illness group of 104 cases,according to the prognosis,severe patients were grouped into a poor prognosis group of 30 cases and a good prognosis group of 74 cases.Clinical data related to the study subjects were collected,enzyme linked immunosorbent assay(ELISA)was applied to detect serum levels of sFlt-1 and sCD163.Multivariate Logistic regression was applied to analyze the factors affecting the prognosis of severe MPP patients.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum sFlt-1 and sCD163 for poor prognosis in severe MPP patients.Result The serum levels of sFlt-1 and sCD163 in the MPP group were obviously higher than those in the control group(P<0.05).The serum levels of sFlt-1 and sCD163 in the severe group were obviously higher than those in the mild group(P<0.05).The serum levels of sFlt-1,sCD163,and CRP in the poor prognosis group were obviously higher than those in the good prognosis group(P<0.05).The results of multivariate Logistic regression analysis showed that sFlt-1 and sCD163 were risk factors for poor prognosis in severe MPP patients(P<0.05).ROC curve results showed that the AUC of serum sFlt-1 and sCD163 levels alone and in combination in predicting poor prognosis in severe MPP patients was 0.846,0.854,and 0.923,respectively,and the combination of the two was better than the single prediction(Z=2.656,2.519,P<0.05).Conclusion Elevated serum sFlt-1 and sCD163 are closely related to poor prognosis in patients with severe MPP,and have certain predictive value for poor prognosis.
作者
路兴中
曹丹丹
李明华
陈丽英
Lu Xingzhong;Cao Dandan;Li Minghua;Chen Liying(Department of Pediatric,Hospital Of Traditional Chinese Medicine Of Qiqihar,Heilongjiang Qiqihar 161000,China;Department of Pediatric,The First Hospital of Qiqihar,Heilongjiang Qiqihar 161000,China)
出处
《新发传染病电子杂志》
2024年第4期39-43,共5页
Electronic Journal of Emerging Infectious Diseases
作者简介
通信作者:陈丽英,Email:1063776069@qq.com。
