摘要
目的:分析256层CT灌注成像参数(CTPI)联合半乳糖凝集素-3(Gal-3)在术前肺癌纵隔淋巴结转移诊断中的应用价值。方法:回顾性分析2022年4月-2023年4月收治的87例肺癌患者的临床资料,根据纵隔淋巴结转移情况分为转移组(n=45)和未转移组(n=42)。另选取2022年4月-2023年4月进行体检的健康人群作为对照组(n=40)。对所有受试者进行血清Gal-3水平检测,并采用Brilliance iCT扫描仪进行CT灌注扫描。比较三组CTPI[表面通透性(PS)、灌注值(PV)、肺动脉血流量(PAF)、血容量(BV)、平均通过时间(MTT)、强化峰值(PEI)、支气管动脉血流量(BAF)]和血清Gal-3水平,并采用受试者工作特征(ROC)曲线评估CTPI、血清Gal-3水平及联合检测在术前肺癌纵隔淋巴结转移中的诊断效能。结果:转移组PS,PV和Gal-3均高于未转移组和对照组,未转移组PS,PV和Gal-3均高于对照组,差异有统计学意义(P<0.05)。ROC曲线分析显示,PS值、PV及Gal-3水平联合检测肺癌纵隔淋巴结转移的线下面积高于各项单独检测,差异有统计学意义(P<0.05)。结论:256层CTPI联合血清Gal-3检测对术前肺癌纵隔淋巴结转移具有较高的诊断价值,可为肺癌患者术前评估提供重要依据。
Objective:To analyze the application value of 256 slice CT perfusion imaging parameters(CTPI)combined with galactose agglutinin 3(Gal-3)in preoperative diagnosis of mediastinal lymph node metastasis in lung cancer.Methods:A retrospective analysis was conducted on the clinical data of 87 lung cancer patients admitted to hospital from April 2022 to April 2023.They were divided into metastatic group(n=45)and non metastatic group(n=42)based on the status of mediastinal lymph node metastasis.We also selected healthy individuals who underwent physical examinations in hospital from April 2022 to April 2023 as the control group(n=40).All subjects were tested for serum Gal-3 levels and CT perfusion scanning was performed using Brilliance iCT scanner.Compare three groups of CTPI[surface permeability(PS),perfusion value(PV),pulmonary artery blood flow(PAF),blood volume(BV),mean transit time(MTT),peak enhancement(PEI),bronchial artery blood flow(BAF)],and serum Gal-3 levels.Evaluate the diagnostic efficacy of CTPI,serum Gal-3 levels,and combined detection in preoperative mediastinal lymph node metastasis of lung cancer using receiver operating characteristic(ROC)curves.Results:The PS,PV and Gal-3 in the metastatic group were significantly higher than those in the non-metastatic group and the control group,while the PS,PV and Gal-3 of the non metastatic group were higher than those of the control group(P<0.05).ROC curve analysis shows that the area under the line of PS,PV and Gal-3 was higher than that of each other,there was significient difference(P<0.05).Conclusion:The combination of 256 layer CTPI and serum Gal-3 levels has high diagnostic value for preoperative mediastinal lymph node metastasis in lung cancer patients,and can provide important basis for preoperative evaluation of lung cancer patients.
作者
张岩
荆利民
王伟
李东
ZHANG Yan;JING Limin;WANG Wei;LI Dong(The First People's Hospital of Xinxiang,Xinxiang 453000,China;Jiaozuo People's Hospital,Jiaozuo 454000,China)
出处
《临床医药实践》
2024年第10期735-738,共4页
Proceeding of Clinical Medicine
关键词
256层CT灌注成像参数
半乳糖凝集素-3
肺癌
纵隔淋巴结转移
诊断价值
256 layer CT perfusion imaging parameters
galactose agglutinin 3
lung cancer
mediastinal lymph node metastasis
diagnostic value
作者简介
张岩(1982-),男,河南省新乡市人,学士学位,主治医师。研究方向:心血管,肺部影像诊断。E-mail:mei719464628913@163.com;通信作者:李东。
