摘要
合欢Albizia julibrissin是一种药食两用的中药材,在临床中应用广泛。合欢的主要药用部位有合欢皮和合欢花,内含多种有效成分,具有抗炎、抗氧化、抗抑郁、镇静催眠等多种药理作用。研究显示合欢皮和合欢花及有效成分能通过调节神经递质表达、减轻氧化应激及炎症反应、调控相关信号通路等机制起到改善及治疗抑郁症、焦虑症等精神疾病的目的。主要对合欢皮、合欢花及有效成分抗抑郁和抗焦虑等治疗精神疾病的药理作用及机制的研究现状进行综述,旨在为合欢作为抗精神疾病药物的开发与应用提供参考。
Albizia julibrissin is a medicinal and edible Chinese herbal medicine,which is widely used in clinical practice.The main medicinal parts of A.julibrissin are bark and flowers,which contain a variety of active ingredients and have many pharmacological effects such as anti-inflammatory,antioxidant,antidepressant,sedative and hypnotic.Studies have shown that the extracts and active ingredients of A.julibrissin can improve and treat mental disorders such as depression and anxiety by regulating the expression of neurotransmitters,reducing oxidative stress and inflammatory response,and regulating related signaling pathways.The research status of the pharmacological effects and mechanisms of the extracts of A.julibrissin and its active ingredients against mental diseases were reviewed,in order to provide reference for the development and application of A.julibrissin as an anti-mental diseases drug.
作者
黄辰杰
樊明理
杜晓娜
施学丽
HUANG Chenjie;FAN Mingli;DU Xiaona;SHI Xueli(Graduate School,Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Fangchenggang Hospital of Traditional Chinese Medicine,Fangchenggang 538000,China;Zhuang Medicine College,Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)
出处
《药物评价研究》
CAS
北大核心
2024年第8期1929-1936,共8页
Drug Evaluation Research
基金
广西自然科学基金重点项目(2023GXNSFDA026048)
广西研究生教育创新计划项目(YCSW2024427)。
关键词
合欢
合欢皮
合欢花
精神疾病
抑郁症
焦虑症
Albizia julibrissin Durazz.
Albiziae Cortex
Albiziae Flos
mental diseases
depression
anxiety
作者简介
第一作者:黄辰杰,男,在读硕士研究生,研究方向为中医药防治情志病。E-mail:1521848943@qq.com;通信作者:施学丽,女,教授,硕士研究生导师,研究方向为中医药、民族医药防治情志病。E-mail:575794426@qq.com。
