摘要
目的对运动干预在肌萎缩侧索硬化患者中的干预效果进行系统评价再评价,为运动干预策略的实施和持续改进提供借鉴。方法计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Embase、Cochrane Library、Web of Science、CINAHL、Campbell协作网、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库等关于肌萎缩侧索硬化运动干预相关的系统评价/Meta分析,检索时限从建库至2023年12月19日。2名接受过循证护理系统培训的研究人员独立进行文献筛选,采用AMSTAR 2进行文献方法学质量评价,采用GRADE系统进行证据分级。结果共纳入8篇系统评价,AMSTAR 2评价结果显示,1篇中等质量,6篇低质量,1篇极低质量。采用GRADE系统对33条结局指标的证据质量评价显示,1条证据为中等质量,24条证据为低质量,8条证据为极低质量。结论运动干预或可改善肌萎缩侧索硬化患者疾病整体功能,不会加重患者的疲劳程度。但考虑纳入研究的数量及质量限制,尚需大样本、高质量的随机对照试验进一步验证运动干预在肌萎缩侧索硬化患者中的效果。
Objective To re-evaluate the effectiveness of exercise interventions in patients with amyotrophic lateral sclerosis(ALS)by conducting a systematic review and provide insights for the implementation and continuous improvement of exercise intervention strategies.Methods A comprehensive search was conducted across databases,including CNKI,Wanfang,VIP,SinoMed,PubMed,Embase,Cochrane Library,Web of Science,CINAHL,Campbell Collaboration,and the Joanna Briggs Institute Evidence-Based Health Care Center Database.The search covered literature from the inception of the databases until December 19,2023.Two researchers trained in evidence-based nursing independently screened the literature.The methodological quality of the included studies was assessed using the AMSTAR 2 tool,and the quality of evidence was graded using the GRADE system.Results Eight systematic reviews were included.The AMSTAR 2 evaluation revealed one review of moderate quality,six of low quality,and one of very low quality.GRADE assessment of 33 outcome indicators showed that one piece of evidence was of moderate quality,24 were of low quality,and eight were of very low quality.Conclusions Exercise interventions may improve overall functional outcomes in ALS patients without exacerbating fatigue.However,due to the limitations in the quantity and quality of the included studies,further large-scale,high-quality randomized controlled trials are needed to verify the effects of exercise interventions in ALS patients.
作者
单静
苗亚杰
刘佳
孙金菊
孟雪
杨梦雪
Shan Jing;Miao Yajie;Liu Jia;Sun Jinju;Meng Xue;Yang Mengxue(Department of Nursing,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neuromuscular Disorders,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《中华现代护理杂志》
2024年第28期3852-3858,共7页
Chinese Journal of Modern Nursing
基金
中华医学会杂志社2022—2023年护理学科研究课题(CMAPH-NRI2022028)
首都医科大学附属北京天坛医院青年基金(2022-YQN-03)。
关键词
肌萎缩侧索硬化
系统评价再评价
循证护理学
运动
Amyotrophic lateral sclerosis
Re-evaluation of systematic reviews
Evidence-based nursing
Exercise
作者简介
通信作者:苗亚杰,Email:miaoyajie@bjtth.org。
