摘要
三基序蛋白28(tripartite motif 28,TRIM28)是一种E3泛素连接酶,属于TRIM(tripartite motif-containing,TRIM)家族,具有典型的RBCC(RING、B-box、Coiled-coil)结构域和多变的羧基端结构域。TRIM28在细胞核和细胞质中均有分布,除了具有E3泛素连接酶活性,还具有SUMO E3泛素连接酶活性,并且可作为转录因子调节靶基因的转录。TRIM28在细胞的增殖与分化过程中发挥重要的作用,同时也参与了癌症相关信号通路,从而促进非小细胞肺癌、乳腺癌和胃癌等多种癌细胞的增殖、侵袭和迁移,抑制细胞凋亡的发生。该文就TRIM28的蛋白结构、生物学功能、信号通路及其在肿瘤发生发展中的作用研究进行综述。
Tripartite motif 28(TRIM28)is an E3 ubiquitin ligase belonging to the tripartite motif-containing(TRIM)family.It has a typical RBCC(RING,B-box,Coiled-coil)domain and a variable C-terminal domain.TRIM28 is distributed in the nucleus and cytoplasm.In addition to E3 ubiquitin ligase activity,it also has SUMO E3 ubiquitin ligase activity and can be used as a transcription factor to regulate the transcription of target genes.TRIM28 plays an important role in cell proliferation and differentiation,and is also involved in cancer-related signaling pathways,thereby promoting the proliferation,invasion,and migration of many common cancer cells such as non-small cell lung cancer,breast cancer,and gastric cancer,and inhibiting the occurrence of apoptosis.In this paper,the protein structure,biological function,signaling pathway of TRIM28,and its role in tumorigenesis and development are reviewed.
作者
侯雪阳
宋丹丹
徐晓珍
肖帅
周策凡
唐景峰
HOU Xueyang;SONG Dandan;XU Xiaozhen;XIAO Shuai;ZHOU Cefan;TANG Jingfeng(Department of Biomedicine/Institute of Biomedicine,College of Bioengineering and Food Science,Hubei University of Technology,Hubei Wuhan 430068,China;National"111"Research Center for Cell Regulation and Molecular Drugs,Hubei University of Technology,Hubei Wuhan 430068,China)
出处
《现代肿瘤医学》
CAS
2024年第18期3589-3596,共8页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(编号:82273970)
湖北工业大学人才引进项目(编号:XJ2022003901)。
作者简介
侯雪阳(1999-),女,河北保定人,在读硕士,主要从事肿瘤调控与分子药物的研究。E-mail:h15100320828@163.com。
