摘要
目的分析肺泡动脉血氧分压差(PA-aDO_(2))检测在肺部感染致急性呼吸窘迫综合征(ARDS)病情评估中的应用价值。方法队列研究。抽取2020年7月至2023年2月河南省职工医院收治的32例肺部感染致ARDS患者作为观察组,另抽取同期行体检健康的32例志愿者作为对照组。检测并比较两组PA-aDO_(2)、第1秒用力呼气容积(FEV1)、最大通气量(MVV)。比较观察组不同急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、不同预后患者的PA-aDO_(2)、FEV1、MVV;采用Pearson法分析PA-aDO_(2)、FEV1、MVV与APACHEⅡ评分、预后的相关性。结果观察组PA-aDO_(2)高于对照组,FEV1、MVV低于对照组(P<0.05)。观察组中,APACHEⅡ评分≥40分、20~40分、<20分者的PA-aDO_(2)依次降低,FEV1、MVV依次升高,组间两两比较差异有统计学意义(P<0.05);预后存活患者PA-aDO_(2)低于死亡患者,FEV1、MVV高于死亡患者(P<0.05)。Pearson分析结果显示,PA-aDO_(2)与FEV1、MVV呈负相关(r=-0.67、-0.66,P均<0.05),PA-aDO_(2)与APACHEⅡ评分、预后死亡呈正相关(P<0.05),FEV1、MVV与APACHEⅡ评分、预后死亡呈负相关(P<0.05)。结论肺部感染致ARDS患者的PA-aDO_(2)较高,依据PA-aDO_(2)可以评估患者的肺功能及病情严重程度,并可预测患者预后。
ObjectiveTo analyze the application value of pulmonary alveolar-arterial oxygen partial pressure difference(PA-aDO_(2))detection in evaluating the condition of acute respiratory distress syndrome(ARDS)caused by pulmonary infection.MethodsA total of 32 patients with ARDS caused by pulmonary infection treated in Henan Provincial Staff Hospital from July 2020 to February 2023 were selected as the observation group for the cohort study.In addition,32 healthy volunteers who underwent physical examination during the same period were selected as the control group.The PA-aDO_(2),forced expiratory volume in 1 second(FEV1),and maximum ventilatory volume(MVV)of the two groups were detected and compared.The PA-aDO_(2),FEV1 and MVV of patients with different scores of acute physiological and chronic health rating scaleⅡ(APACHEⅡ)and different prognoses were compared in the observation group.Pearson correlation was used to analyze the correlation of PA-aDO_(2),FEV1 and MVV with APACHEⅡscore and prognosis.ResultsThe PA-aDO_(2) in the observation group was higher than that in the control group,while FEV1 and MVV in the observation group were lower than those in the control group(P<0.05).In the observation group,the PA-aDO_(2) of patients with APACHEⅡscores≥40,within 20-40,and<20 decreased sequentially,while the FEV1 and MVV increased sequentially,and the difference in pairwise comparisons was statistically significant(P<0.05).The PA-aDO_(2) of survival patients was lower than that of the dead,while FEV1 and MVV were higher than that of the dead(P<0.05).The results of Pearson analysis showed that PA-aDO_(2) was negatively correlated with FEV1 and MVV(r=-0.67,-0.66;both P<0.05),and the PA-aDO_(2) was positively correlated with APACHEⅡscore and death(P<0.05),while FEV1,MVV were negatively correlated with APACHEⅡscore and death(P<0.05).ConclusionsThe level of PA-aDO_(2) is higher in patients with ARDS caused by pulmonary infection.PA-aDO_(2) can be used to evaluate lung function,severity of the disease,and predict the prognosis of patients.
作者
孙丹
钱鹏
高勇才
Sun Dan;Qian Peng;Gao Yongcai(Department of Clinical Laboratory,Henan Provincial Staff Hospital,Zhengzhou 450052,China)
出处
《中国实用医刊》
2024年第14期72-75,共4页
Chinese Journal of Practical Medicine
关键词
呼吸窘迫综合征
肺部感染
肺泡动脉血氧分压差
Respiratory distress syndrome
Pulmonary infection
Alveolar-arterial oxygen partial pressure difference
作者简介
通信作者:孙丹,Email:hnszgyy_sd@163.com。
