摘要
目的探讨维持性血液透析(MHD)患者血清骨桥蛋白(OPN)、成纤维细胞生长因子23(FGF23)水平及对血管钙化的预测价值。方法选取河南南阳市第二人民医院在2021年1月至2023年12月期间收治的116例MHD患者为研究对象,根据患者是否出现血管钙化分为钙化组74例及无钙化组42例,比较两组血清OPN、FGF23水平,分析MHD患者血管钙化危险因素,采用ROC曲线分析血清OPN、FGF23水平对MHD患者血管钙化的预测价值。结果钙化组透析龄、血磷、碱性磷酸酶(ALP)、C反应蛋白(CRP)、全段甲状旁腺激素(iPTH)、OPN、FGF23高于无钙化组,差异有统计学意义(P<0.05);MHD患者血清OPN、FGF23水平为重度钙化>中度钙化>轻度钙化,差异有统计学意义(P<0.05);Spearman分析显示,MHD患者血管钙化程度与血清OPN、FGF23水平呈正相关(r=0.889、0.863,P<0.05);Logistic分析显示,MHD患者透析龄、血磷、ALP、CRP、iPTH、OPN、FGF23升高是血管钙化的危险因素(P<0.05);受试者工作特征曲线(ROC)曲线分析显示,血清OPN、FGF23水平单一及联合预测MHD患者血管钙化的曲线下面积(AUC)分别为0.845、0.891、0.948,联合预测优于单一预测(P<0.05)。结论MHD患者血清OPN、FGF23水平与血管钙化程度呈正相关,OPN、FGF23联合检测对MHD患者血管钙化具有较高的预测价值。
Objective To investigate the serum levels of osteopontin(OPN)and fibroblast growth factor 23(FGF23)in patients with maintenance hemodialysis(MHD)and their predictive value on vascular calcification.Methods A total of 116 MHD patients admitted to the Second People's Hospital of Nanyang City,Henan Province from January 2021 to December 2023 were selected as the study objects.Ac⁃cording to whether the patients had vascular calcification,they were divided into a calcification group(74 cases)and a non⁃calcification group(42 cases).Serum OPN and FGF23 levels were compared between the two groups,and the risk factors of vascular calcification in MHD patients were analyzed.ROC curve was used to analyze the predictive value of serum OPN and FGF23 levels on vascular calcification in MHD patients.Results The dialysis age,blood phosphorus,alkaline phosphatase(ALP),C⁃reactive protein(CRP),com⁃plete parathyroid hormone(iPTH),OPN and FGF23 in the calcification group were higher than those in the non⁃calcification group,and the differences were statistically significant(P<0.05).The levels of serum OPN and FGF23 in MHD patients were severe calcification group>moderate calcification group>mild calcification group,the difference was statistically significant(P<0.05).Spearman correlation analysis showed that the de⁃gree of vascular calcification in MHD patients was positively correlated with serum OPN and FGF23 levels(r=0.889,0.863,P<0.05).Logistic analysis showed that the increase of dialysis age,blood phosphorus,ALP,CRP,iPTH,OPN and FGF23 in MHD patients were risk factors for vascular calcification(P<0.05).Receiver operating characteristic curve(ROC)curve analysis showed that the area under the curve(AUC)of serum OPN and FGF23 were 0.845,0.891 and 0.948,respectively,and the combined prediction was better than the single prediction(P<0.05).Conclusion Serum OPN and FGF23 levels are positively correlated with the de⁃gree of vascular calcification in MHD patients,and the combined detection of OPN and FGF23 has high pre⁃dictive value for vascular calcification in MHD patients.
作者
陈庆云
马亚琼
苏裕
CHEN Qingyun;MA Yaqiong;SU Yu(Department of Nephrology,The Second Peoples Hospital of Nanyang City,Nanyang,Henan,China,473000)
出处
《分子诊断与治疗杂志》
2024年第8期1412-1415,1424,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省科技厅项目(202204036X)。
作者简介
通信作者:陈庆云,E⁃mail:cqy0377@126.com。
