摘要
目前,临床上对胃肠道恶性肿瘤的治疗仍然以放化疗为主,但是患者对放化疗药物易产生耐药性,严重影响患者的生活质量。研究发现,肿瘤化疗药物的耐药性是由铁的累积和氧化还原稳态失调所造成,也许调控铁死亡途径可以为胃肠道恶性肿瘤耐药的治疗带来新的机遇。本文对铁死亡的特征、调控机制进行了系统的总结与分析,同时概述了铁死亡不同途径对改善胃肠道恶性肿瘤细胞耐药性的研究进展,旨在为胃肠道恶性肿瘤耐药患者的治疗提供新的思路和方向。
At present,the clinical treatment of gastrointestinal malignant tumors primarily relies on radiotherapy and chemotherapy,but patients are prone to developing drug resistance to these treatments,which seriously affects their quality of life.Studies have found that resistance to tumor chemotherapeutic drugs is caused by iron accumulation and redox homeostasis imbalance.Perhaps the regulation of ferroptosis pathways could bring new opportunities for reducing drug resistance in gastrointestinal malignant tumors.This paper systematically summarizes and analyzes the characteristics and regulatory mechanisms of ferroptosis,and outlines the research progress of different ferroptosis pathways in reducing drug resistance of gastrointestinal malignant tumor cells,aiming to provide new ideas and directions for treating patients with drug resistance of gastrointestinal malignant tumors.
作者
陈鑫源
唐梅文
吴成挺
熊常州
王婷
崔引航
谢家诚
CHEN Xinyuan;TANG Meiwen;WU Chengting;XIONG Changzhou;WANG Ting;CUI Yinhang;XIE Jiacheng(Guangxi University of Chinese Medicine,Nanning,Guangxi 530000,China;Department of Spleen and Stomach Diseases,Xianhu Branch of the First Hospital of Guangxi University of Chinese Medicine,Nanning,Guangxi 530000,China;Ruikang Hospital of Guangxi University of Chinese Medicine,Nanning,Guangxi 530000,China)
出处
《湖南中医药大学学报》
CAS
2024年第8期1549-1556,共8页
Journal of Hunan University of Chinese Medicine
基金
国家自然科学基金地区基金项目(82360959)
广西自然科学基金青年科学基金(2024GXNSFBA010160)
广西研究生教育创新计划项目(YCBZ2023156)。
关键词
胃肠道恶性肿瘤
铁死亡
耐药
脂质过氧化代谢
谷胱甘肽代谢
氨基酸代谢
铁代谢
gastrointestinal malignant tumors
ferroptosis
drug resistance
lipid peroxidation metabolism
glutathione metabolism
amino acid metabolism
iron metabolism
作者简介
通信作者:唐梅文,男,教授,博士研究生导师,E-mail:tangmw@gxtcmu.edu.cn。
