四黄生肌汤在热毒炽盛证肛周脓肿术后患者中的应用效果被引量：1

Effect of Sihuang Shengji Decoction(四黄生肌汤)on Postoperative Patients with Perianal Abscess of Heat Toxin Exuberance Syndrome

在线阅读下载PDF

导出

摘要目的探讨四黄生肌汤在热毒炽盛证肛周脓肿术后患者中的应用效果。方法采用随机数字表法将100例2021年8月—2022年4月该院收治的肛周脓肿术后患者分为对照组和试验组,各50例。对照组给予高锰酸钾溶液坐浴,甲硝唑氯化钠注射液、0.9%氯化钠溶液反复清洗及硫酸庆大霉素注射液纱条填塞,试验组在对照组基础上加服四黄生肌汤,两组均治疗10 d。比较两组治疗10 d后的效果,创面愈合情况,治疗前、治疗10 d后的中医证候积分、细胞因子及治疗期间的安全性。结果与对照组比较,治疗10 d后试验组总有效率较高[96.00%(48/50)vs 78.00%(39/50),P<0.05]。试验组创面腐肉脱落、创面愈合时间短于对照组,治疗10 d后的创面疼痛、红肿、分泌物、肉芽形态评分低于对照组(P<0.05)。与治疗前比较,治疗10 d后,两组口干便秘、肛门红肿、夜寐不安、恶寒发热评分及血清白细胞介素-1β(IL-1β)、C反应蛋白(C-reactive protein,CRP)、激活素A(activin A,ACTA)水平降低,试验组低于对照组(P<0.05);两组血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平升高,试验组高于对照组(P<0.05)。与对照组比较,治疗期间试验组并发症总发生率较低[4.00%(2/50)vs 14.00%(7/50),P<0.05]。结论四黄生肌汤可明显改善热毒炽盛证肛周脓肿术后患者中医证候,缓解炎症反应,促进新生血管生成,进而有助于加快患者创面愈合,提高治疗效果,且具有较高安全性。 Objective To investigate the effect of Sihuang Shengji Decoction(四黄生肌汤)on postoperative patients with perianal abscess of heat toxin exuberance syndrome.Methods A hundred cases of postoperative patients with perianal abscess of heat toxin exuberance syndrome admitted to the hospital from August 2021 to April 2022 were selected as the research objects,and they were divided into the control group and the test group by random number table method,each with 50 cases.The control group was given potassium permanganate solution for hip bath,metronidazole sodium chloride injection,0.9%sodium chloride solution for repeated cleaning and gentamycin sulfate injection gauze packing.The test group was given Sihuang Shengji Decoction on the basis.Both groups were treated for 10 d.The effects after 10 d of treatment,wound healing,scores of traditional Chinese medicine symptoms,cytokine before and after 10 d of treatment and the security during treatment were compared between the two groups.Results Compared with that of the control group,the total effective rate of the test group was higher after 10 d of treatment[96.00%(48/50)vs 78.00%(39/50),P<0.05].Compared with those of the control group,the times of wound decay and wound healing in the test group were shorter,and after 10 d of treatment,the scores of wound pain,redness and swelling,secretion and granulation morphology in the test group were lower(P<0.05).Compared with those before treatment,after 10 d of treatment,the scores of dry mouth and constipation,anal redness and swelling,restless sleep,aversion to cold and fever,serum levels of interleukin-1β(IL-1β),C-reactive protein(CRP)and activin A(ACTA)in the two groups decreased,and the levels of the test group were lower than those of the control group(P<0.05).The serum level of vascular endothelial growth factor(VEGF)in both groups increased,and the level of the test group was higher than that of the control group(P<0.05).Compared with that of the control group,the total incidence of complications in the test group during treatment period was lower[4.00%(2/50)vs 14.00%(7/50),P<0.05].Conclusion Sihuang Shengji Decoction could obviously improve the traditional Chinese medicine symptoms of postoperative patients with perianal abscess of heat toxin exuberance syndrome,alleviate the inflammatory reaction,promote angiogenesis,and then help to promote the wound healing of patients and improve the treatment effect,with high safety.

作者师九平卢临生赵晨翔贾增增王建忠 SHI Jiuping;LU Linsheng;ZHAO Chenxiang;JIA Zengzeng;WANG Jianzhong(Linfen Central Hospital,Linfen 041000,Shanxi,China)

机构地区临汾市中心医院

出处《辽宁中医杂志》 CAS 北大核心 2024年第8期119-122,共4页 Liaoning Journal of Traditional Chinese Medicine

关键词肛周脓肿热毒炽盛证四黄生肌汤高锰酸钾甲硝唑庆大霉素中医证候创面愈合炎症 perianal abscess heat toxin exuberance syndrome Sihuang Shengji Decoction(四黄生肌汤) potassium permanganate metronidazole gentamicin traditional Chinese medicine symptom wound healing inflammation