摘要
目的分析血清脱嘌呤脱嘧啶核酸内切酶1自身抗体(APE1-AAbs)、生长分化因子15(GDF-15)水平及对结直肠癌患者术后复发转移的预测价值。方法选取52例结直肠癌患者为观察组,并根据预后情况分为术后复发转移组(n=15)和术后未复发转移组(n=37)。选取同期正常体检健康者52例为对照组。检测APE1-AAbs、GDF-15水平。采用Pearson相关性分析法分析APE1-AAbs、GDF-15与结直肠癌术后复发转移的相关性。绘制受试者工作特征(ROC)曲线分析APE1-AAbs、GDF-15对结直肠癌术后复发转移的预测价值。结果观察组的APE1-AAbs、GDF-15水平高于对照组,差异有统计学意义(P<0.05)。术后复发转移组的APE1-AAbs、GDF-15水平高于术后未复发转移组,差异有统计学意义(P<0.05)。APE1-AAbs、GDF-15水平与结直肠癌术后复发转移呈正相关(P<0.05)。APE1-AAbs、GDF-15联合预测结直肠癌术后复发转移的价值高于APE1-AAbs、GDF-15单独预测,差异有统计学意义(P<0.05)。结论APE1-AAbs、GDF-15在结直肠癌患者血清中呈高表达。APE1-AAbs、GDF-15或可作为结直肠癌术后复发转移的标志物。
Objective To analyze the serum levels of apurinic/apyrimidinic endonuclease 1 autoantibodies(APE1-AAbs)and growth differentiation factor 15(GDF-15)and their predictive value for postoperative recurrence and metastasis in patients with colorectal cancer.Methods Fifty-two patients with colorectal cancer were selected as observation group,and were divided into postoperative recurrence and metastasis group(n=15)and non-recurrence and metastasis group(n=37)according to prognosis.Fifty-two healthy individuals undergoing routine physical examination during the same period were selected as the control group.The levels of APE1-AAbs and GDF-15 were measured.Pearson correlation analysis was used to analyze the correlations of APE1-AAbs,GDF-15 with post-surgical recurrence and metastasis of colorectal cancer.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of APE1-AAbs and GDF-15 for post-surgical recurrence and metastasis of colorectal cancer.Results The levels of APE1-AAbs and GDF-15 in the observation group were significantly higher than those in the control group(P<0.05).The levels of APE1-AAbs and GDF-15 in the postoperative recurrence and metastasis group were significantly higher than those in the non-recurrence and metastasis group(P<0.05).There was a positive correlation between the levels of APE1-AAbs,GDF-15 and post-surgical recurrence and metastasis of colorectal cancer(P<0.05).The combined use of APE1-AAbs and GDF-15 had higher predictive value for post-surgical recurrence and metastasis of colorectal cancer than either single prediction(P<0.05).Conclusion APE1-AAbs and GDF-15 are highly expressed in the serum of colorectal cancer patients.APE1-AAbs and GDF-15 may serve as markers for post-surgical recurrence and metastasis of colorectal cancer.
作者
沈磊
刘志宁
杨金珠
宋琪
SHEN Lei;LIU Zhining;YANG Jinzhu;SONG Qi(Department of Oncology,the Third People′s Hospital of Hefei in Anhui Province,Hefei Third Clinical College of Anhui Medical University,Hefei,Anhui,230051;Department of General Surgery,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui,230011)
出处
《实用临床医药杂志》
CAS
2024年第12期72-76,共5页
Journal of Clinical Medicine in Practice
基金
安徽省教育厅高校科学研究重点项目(KJ2021A0317)
安徽省合肥市卫健委应用医学研究项目(Hwk2023zc013)。
关键词
结直肠癌
脱嘌呤脱嘧啶核酸内切酶1自身抗体
生长分化因子15
术后复发转移
colorectal cancer
apurinic/apyrimidinic endonuclease 1 autoantibodies
growth differentiation factor 15
recurrence and metastasis after surgery
