摘要
目的分析红细胞沉降率与带状疱疹后遗神经痛(PHN)患者应用普瑞巴林治疗效果的关系,为提高PHN患者治疗效果提供经验指导。方法纳入驻马店市中心医院2021年6月至2023年4月治疗的PHN患者作为研究对象,给予患者普瑞巴林每次75 mg、每日2次治疗14 d,治疗前检测红细胞沉降率、C反应蛋白、白细胞介素-6等指标,治疗14 d后判定疗效,分析红细胞沉降率与PHN患者应用普瑞巴林治疗效果的关系。结果本研究共纳入126例PHN患者,治疗期间剔除6例,最终共有120例患者进入本次研究。120例患者普瑞巴林治疗总有效率为81.67%(98/120)。无效组C反应蛋白、白细胞介素-6、白细胞计数、红细胞沉降率高于有效组,差异有统计学意义(P<0.05);经logistic回归分析显示,C反应蛋白、白细胞介素-6、白细胞计数、红细胞沉降率升高是PHN患者普瑞巴林治疗无效的危险因素(OR>1,P<0.05)。绘制受试者工作特征曲线,结果显示,C反应蛋白、白细胞介素-6、白细胞计数及红细胞沉降率对PHN患者普瑞巴林治疗效果均有一定的预测价值,且红细胞沉降率预测价值最高。结论红细胞沉降率与PHN患者普瑞巴林治疗效果密切相关,检测红细胞沉降率水平能为PHN患者普瑞巴林治疗效果的预测提供重要价值。
Objective To analyze the relationship between erythrocyte sedimentation rate and the therapeutic effect of pregabalin in patients with postherpetic neuralgia(PHN),so as to provide empirical guidance for improving the therapeutic effect of PHN patients.Methods The PHN patients treated in Zhumadian Central Hospital from June 2021 to April 2023 were included as the research objects.The patients were given 75 mg pregabalin twice a day for 14 days.Before treatment,the erythrocyte sedimentation rate,C-reactive protein,interleukin-6 and other indicators were detected.After 14 days of treatment,the therapeutic effect was determined.The relationship between erythrocyte sedimentation rate and the therapeutic effect of pregabalin in PHN patients was analyzed.Results A total of 126 PHN patients were included in this study,and 6 were excluded during the treatment period.In the end,a total of 120 patients entered this study.The total effective rate of pregabalin in 120 patients was 81.67%(98/120).The C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate in the ineffective group were higher than those in the effective group,with statistical significant differences(P<0.05).Logistic regression analysis showed that the increase of C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate were the risk factors for the ineffective treatment of pregabalin in PHN patients(OR>1,P<0.05).The receiver operating characteristic curve of the subjects was drawn.The results showed that C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate had certain predictive value for the treatment effect of pregabalin in PHN patients,and erythrocyte sedimentation rate had the highest predictive value.Conclusion Erythrocyte sedimentation rate is closely related to the therapeutic effect of pregabalin in PHN patients,and detection of erythrocyte sedimentation rate can provide important value for predicting the therapeutic effect of pregabalin in PHN patients.
作者
王林丽
WANG Linli(Department of Pain,Zhumadian Central Hospital,Zhumadian 463000,China)
出处
《河南医学研究》
CAS
2024年第14期2572-2576,共5页
Henan Medical Research
