摘要
目的:探讨摩罗丹联合四联疗法治疗幽门螺杆菌(Hp)相关慢性萎缩性胃炎(CAG)的效果。方法:选取2022年3月—2023年2月福建医科大学附属第二医院收治的96例Hp相关CAG患者为研究对象,按随机数表法分为对照组(n=48)、观察组(n=48)。对照组予以四联疗法,观察组予以摩罗丹联合四联疗法。比较两组临床疗效、Hp阴性率、中医症候积分、慢性胃炎患者生命质量测定量表(QLICD-CG)评分及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、生长激素调素水平。结果:观察组临床总有效率为95.83%,高于对照组的83.33%,差异有统计学意义(P<0.05)。观察组Hp阴性率为100.00%,高于对照组的93.75%,差异无统计学意义(P>0.05)。治疗后,观察组中医症候积分低于对照组,QLICD-CG评分高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清TNF-α、IL-6、IL-1β水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清PGⅠ、生长激素调素水平高于对照组,差异有统计学意义(P<0.05)。结论:摩罗丹联合四联疗法治疗Hp相关CAG的效果较好,可有效抑制炎症反应,调节PGⅠ、生长激素调素水平,改善患者临床症状及生活质量。
Objective:To explore the effect of Moluodan combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)-related chronic atrophic gastritis(CAG).Method:A total of 96 patients with Hp-related CAG admitted to the Second Affiliated Hospital of Fujian Medical University from March 2022 to February 2023 were selected as the research objects.They were divided into control group(n=48)and observation group(n=48)according to the random number table method.The control group was given quadruple therapy,and the observation group was given Moluodan combined with quadruple therapy.The clinical efficacy,Hp-negative rate,traditional Chinese medicine syndrome score,quality of life instruments for chronic diseases-chronic gastritis(QLICD-CG)score and serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β),pepsinogenⅠ(PG-Ⅰ),pepsinogenⅡ(PG-Ⅱ)and ghrelin levels were compared between the two groups.Result:The total clinical effective rate of the observation group was 95.83%,higher than 83.33%of the control group,and the difference was statistically significant(P<0.05).The Hp-negative rate in the observation group was 100.00%,which was higher than 93.75%in the control group,but there was no statistically significant(P>0.05).After treatment,the traditional Chinese medicine syndrome score of the observation group was lower than that of the control group,and the QLICD-CG score was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the serum levels of TNF-α,IL-6 and IL-1βin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum PG-Ⅰand ghrelin in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Moluodan combined with quadruple therapy is effective in the treatment of Hp-related CAG,which can effectively inhibit inflammatory response,regulate PGⅠand ghrelin levels,and improve clinical symptoms and quality of life of patients.
作者
陈重谕
CHEN Chongyu(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)
出处
《中外医学研究》
2024年第20期131-135,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
