摘要
目的:观察拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果。方法:选取2021年5月至2022年5月该院收治的90例妊娠期高血压患者进行前瞻性研究,按随机数字表法将其分为观察组和对照组各45例。对照组采用硫酸镁治疗,观察组在对照组基础上联合拉贝洛尔治疗,比较两组治疗前后血压水平、血管内皮功能指标[超氧化物歧化酶(SOD)、内皮素-1(ET-1)、一氧化氮(NO)]水平、氧化应激指标[丙二醛(MDA)、髓过氧化物酶(MPO)]水平,以及不良妊娠结局发生率和不良反应发生率。结果:治疗后,观察组舒张压、收缩压水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组SOD、NO水平均高于对照组,ET-1水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组MDA、MPO水平均低于对照组,差异有统计学意义(P<0.05);观察组不良妊娠结局发生率为2.22%(1/45),低于对照组的22.22%(10/45),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉贝洛尔联合硫酸镁治疗妊娠期高血压患者可降低血压水平,改善血管内皮功能指标水平,降低氧化应激指标水平和不良妊娠结局发生率,效果优于单纯硫酸镁治疗。
Objective:To observe effects of Labetalol combined with Magnesium sulfate in the treatment of patients with gestational hypertension.Methods:A prospective study was conducted on 90 patients with gestational hypertension admitted to the hospital from May 2021 to May 2022.According to the random number table method,they were divided into observation group and control group,45 cases in each group.The control group was treated with Magnesium sulfate,while the observation group was treated with Labetalol on the basis of that of the control group.The blood pressure level,the vascular endothelial function index[superoxide dismutase(SOD),endothelin-1(ET-1),nitric oxide(NO)]levels,the oxidative stress index[malondialdehyde(MDA),myeloperoxidase(MPO)]levels before and after the treatment,and the incidence of adverse pregnancy outcomes,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of diastolic blood pressure and systolic blood pressure in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of SOD and NO in the observation group were higher than those in the control group,the level of ET-1 was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MDA and MPO in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 2.22%(1/45),which was lower than 22.22%(10/45)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Labetalol combined with Magnesium sulfate can reduce the blood pressure levels,improve the vascular endothelial function index levels,reduce the oxidative stress index levels and the incidence of adverse pregnancy outcomes in the patients with gestational hypertension.Moreover,it is superior to single Magnesium sulfate treatment.
作者
李文君
LI Wenjun(Department of Obstetrics of Luohe Maternal and Child Health Hospital,Luohe 462000 Henan,China)
出处
《中国民康医学》
2024年第14期60-62,66,共4页
Medical Journal of Chinese People’s Health
关键词
妊娠期高血压
拉贝洛尔
硫酸镁
血压
血管内皮
氧化应激
不良妊娠结局
Gestational hypertension
Labetalol
Magnesium sulfate
Blood pressure
Vascular endothelium
Oxidative stress
Adverse pregnancy outcome
作者简介
李文君(1989.12-),女,汉族,河南漯河人,本科,主治医师,研究方向为产科。
