摘要
目的 探究对子痫前期合并胎儿生长受限患者采取拉贝洛尔与低分子肝素强化治疗后的效果。方法 简单随机选取2021年6月-2023年6月滕州市中心人民医院收治的120例子痫前期合并胎儿生长受限患者为研究对象,采用随机数表法分成两组,每组60例。对照组接受常规治疗,观察组在对照组基础上接受拉贝洛尔结合低分子肝素强化治疗。对比胎盘血流灌注、胎儿发育水平、凝血功能及临床相关指标。结果 治疗后,观察组脐动脉收缩期峰值/舒张末期血流速度为(2.46±0.15),低于对照组的(2.99±0.19),差异有统计学意义(t=16.959,P<0.05)。观察组的脐动脉搏动指数、脐动脉阻力指数均低于对照组,差异有统计学意义(P均<0.05)。观察组胎儿发育水平、凝血功能水平优于对照组,差异有统计学意义(P均<0.05)。两组分娩时的孕周、分娩出血量、新生儿的出生体质量对比,差异无统计学意义(P均>0.05)。结论 针对子痫前期合并胎儿生长受限,实施拉贝洛尔结合低分子肝素强化治疗,有助于改善血流灌注、凝血功能,促使胎儿生长发育。
Objective To investigate the effect of labetalol and low molecular heparin intensive treatment for patients with preeclampsia combined with fetal growth restriction.Methods A total of 120 patients with preeclampsia com-bined with fetal growth restriction admitted to Tengzhou Central People's Hospital from June 2021 to June 2023 were simple randomly selected as the study objects and divided into two groups by random number table method,with 60 cases in each group.The control group received conventional treatment,and the observation group received intensive treatment with labetalol combined with low molecular weight heparin on the basis of control group.Placental blood perfusion,fetal development level,coagulation function and clinical related indexes were compared.Results After treatment,the peak systolic/end-diastolic blood flow velocity of umbilical artery in observation group was(2.46±0.15),which was lower than that in control group(2.99±0.19),and the difference was statistically significant(t=16.959,P<0.05).The pulse index of umbilical artery and resistance index of umbilical artery in observation group were lower than those in control group,and the differences were statistically significant(both P<0.05).The fetal development level and coagulation function level in the observation group were better than those in the control group,and the differ-ences were statistically significant(both P<0.05).There was no statistically significant difference in gestational week,delivery blood loss and birth weight between the two groups(all P>0.05).Conclusion For preeclampsia combined with fetal growth restriction,the implementation of labetalol combined with low molecular heparin intensive treatment can help to improve blood perfusion,coagulation function and promote fetal growth and development.
作者
鲁晨
王慧
李君
LU Chen;WANG Hui;LI Jun(Department of Obstetrics,Tengzhou Central People's Hospital,Tengzhou,Shandong Province,277500 China;Department of Gynecology,Zaozhuang Shanting District Sangcun Town Central Health Hospital,Tengzhou,Shandong)
出处
《中外医疗》
2024年第14期114-117,共4页
China & Foreign Medical Treatment
关键词
拉贝洛尔
低分子肝素强化
子痫前期
胎儿生长受限
Labetalol
Low molecular heparin intensive
Preeclampsia
Fetal growth restriction
作者简介
鲁晨(1980-),女,本科,主治医师,研究方向为产科;通信作者:李君(1979-),女,硕士,主治医师,研究方向为产科,E-mail:ljsjz0416@163.com。
