摘要
干眼是一种发病机制复杂、受多因素影响的眼表疾病,以持续性泪膜不稳定导致眼部不适、视力受损为主要特征。干燥综合征是一种主要累及泪腺和唾液腺等外分泌腺的系统性自身免疫性疾病,干眼中仅有10%是由干燥综合征导致的,它会导致严重的眼部刺激和视觉障碍。目前针对干眼的研究主要集中在发病率较高的睑板腺功障碍型干眼,对于干燥综合征型干眼的发病机制研究较少,本文将从泪腺及角膜神经异常、蛋白质组学特征的改变、泪液渗透压升高等方面对干燥综合征型干眼的发病因素展开综述,希望为干燥综合征型干眼的亚临床预防、临床治疗提供新方向。
Dry eye is a kind of ocular surface disease with complex pathogenesis and multi-factor influence.The main characteristics of dry eye are ocular discomfort and visual impairment caused by persistent tear film instability.Sjögren’s syndrome is a systemic autoimmune disease that mainly involves exocrine glands such as lacrimal and salivary glands.Only 10%of dry eyes are caused by Sjögren’s syndrome,which causes severe eye irritation and visual impairment.Currently,studies on dry eye mainly focus on metaromian gland dysfunction dry eye with a high incidence,while there are few studies on the pathogenesis of Sjögren’s type dry eye.This paper will review the pathogenesis of Sjögren’s type dry eye from the aspects of neural abnormalities of lacrimal gland and cornea,changes in proteomic characteristics,and elevated osman pressure of tears.It is hoped to provide a new direction for subclinical prevention and treatment of Sjögren’s syn⁃drome type dry eye.
作者
张越鑫
李锦玉
郝彦淞
姜善好
Zhang Yuexin;Li Jinyu;Hao Yan-song;Jiang Shanhao(Department of Ophthalmology,Binzhou Medical College Yantai Affiliated Hospital,Binzhou 264003,China;The Second Clinical College of Binzhou Medical College,Binzhou 264100,China)
出处
《临床眼科杂志》
2024年第3期279-283,共5页
Journal of Clinical Ophthalmology
关键词
干眼
干燥综合征
神经异常
蛋白质组学特征的改变
泪膜渗透压升高
Dry eyes
Sjögren’s syndrome
Neuropathy
Changes in proteomic characteristics
Elevated osmotic pressure of tear film
作者简介
通信作者:姜善好(Email:2602192141@qq.com)。
