摘要
目的通过检测老年良性前列腺增生(BPH)患者的糖脂代谢相关指标,评价其与BPH的相关性,探讨将糖脂代谢相关指标纳入BPH常规检测的可能性,进一步对老年BPH患者治疗提出指导性建议。方法选取2021年7月至2022年6月于枣庄市立医院就诊的85例BPH患者设为BPH组,同期于本院体检的54例健康人员设为健康对照组。检测两组研究对象的糖化白蛋白(GA)、血清白蛋白(ALB)、总胆汁酸(TBA)、1,5-脱水-D-山梨醇(1,5-AG)以及丙酮酸(PYR)和糖化血红蛋白(HbA1c)水平。采用Pearson分析探讨BPH与各指标间的相关性,绘制受试者工作特征(ROC)曲线,以曲线下面积(AUC)评价相关指标对BPH的诊断价值。结果BPH组的BMI显著高于健康对照组(P<0.001)。BPH组的ALB、1,5-AG水平显著低于健康对照组,HbA1c显著高于健康对照组(P<0.01)。BMI、HbA1c与BPH发生呈正相关,ALB和1,5-AG与BPH发生呈负相关(P<0.05)。ALB、1,5-AG和HbA1c诊断BPH的AUC分别为0.796、0.701和0.656。结论ALB、1,5-AG水平降低以及HbA1c升高是BPH患者疾病进展的危险因素,建议将糖脂代谢相关指标ALB、1,5-AG和HbA1c纳入BPH常规检测。
Objective Through the detection of glucose and lipid metabolism related indicators in elderly patients with benign prostatic hyperplasia(BPH),to evaluate the correlation between them and BPH,to explore the possibility of incorporating glucose and lipid metabolism related indicators into routine detection of BPH,and to further provide guidance for the treatment of elderly patients with BPH.Methods A total of 85 patients with BPH who were admitted in Zaozhuang Municipal Hospital from July 2021 to June 2022 were included in BPH group,and 54 healthy people who underwent physical examination in the hospital during the same period were included in healthy control group.The levels of glycated albumin(GA),serum albumin(ALB),total bile acid(TBA),1,5-anhydro-D-glucitol(1,5-AG),pyruvic acid(PYR)and glycosylated hemoglobin(HbA1c)of the two groups were detected.Pearson analysis was used to explore the correlation between BPH and each index,and the receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of related indicators for BPH with the area under the curve(AUC).Results The BMI of the BPH group was significantly higher than that of the healthy control group(P<0.001).The levels of ALB and 1,5-AG in the BPH group were significantly lower than those in the healthy control group,and HbA1c was significantly higher than that in the healthy control group(P<0.01).BMI and HbA1c were positively correlated with the occurrence of BPH,while ALB and 1,5-AG were negatively correlated with the occurrence of BPH(P<0.05).The AUC of ALB,1,5-AG and HbA1c in diagnosis of BPH were 0.796,0.701 and 0.656,respectively.Conclusion The decrease of ALB 1,5-AG levels and the increase of HbA1c are risk factors for the disease progression of BPH patients.It is suggested that ALB,1,5-AG and HbA1c should be included in the routine detection of BPH.
作者
姜家利
陈维霞
张义
高玉强
刘晶
张芬
JIANG Jiali;CHEN Weixia;ZHANG Yi;GAO Yuqiang;LIU Jing;ZHANG Fen(Zaozhuang Municipal Hospital,Zaozhuang 277102,China)
出处
《临床医学研究与实践》
2024年第19期21-24,共4页
Clinical Research and Practice
基金
国家重点研发计划“主动健康和老龄化科技应对”重点专项(No.2021YFC2009300)。
作者简介
姜家利(1974-),男,副主任技师,硕士。研究方向:代谢性疾病及临床生化检验。
