摘要
乳腺癌是全球女性最常见的恶性肿瘤,2020年GLOBOCAN流行病学数据显示,乳腺癌首次超过肺癌成为全球第一高发的恶性肿瘤,严重威胁女性健康。相较于欧美人群,中国女性患者的乳腺癌发病率相对较低,但是随着近年来生活方式、饮食习惯的改变等,中国人群乳腺癌发病逐年增加。中国2020年年龄标化的乳腺癌发病率达到39.1/10万,新发乳腺癌达41.6万例,占全球每年新发乳腺癌总人数的18.4%。乳腺癌防治工作也日益严峻,其中,三阴性乳腺癌作为一种恶性程度高、预后较差的乳腺癌亚型,由于以往缺乏明确的治疗靶点,近年来治疗进展缓慢。尤其是晚期三阴性乳腺癌的治疗,由于治疗手段相对有限,有待进一步优化治疗建议。因此,在中国抗癌协会乳腺癌专业委员会、中国抗癌协会国际医疗交流分会和中国医师协会肿瘤医师分会乳腺癌学组的倡导下,中国乳腺癌各学科诊疗专家组结合国内外最新研究证据、治疗理念和经验,制定了中国晚期三阴性乳腺癌临床诊疗指南(2024版),旨在优化中国晚期三阴性乳腺癌精准治疗决策。
Breast cancer ranks as the most common female malignancy worldwide.Data from GLOBOCAN 2020 showed that breast cancer surpassed lung cancer and become the leading malignancy globally which was a serious threat to women's health.Different from Caucasian,there is a lower prevalence of breast cancer in Chinese women.However,the age-standardized incidence rate of breast cancer in China has reached to 39.1 per 100,000 in 2020,with 416,000 new cases,accounting for 18.4%of global breast cancer burden,due to multiple factors such as lifestyle and dietary habits changes in recent years.The treatment and prevention of breast cancer are becoming increasingly a tuff task.In addition,triple-negative breast cancer(TNBC)is a subtype with higher malignancy and worse prognosis.Due to lack of specific therapeutic targets,less treatment progress has been made in recent years.There is even less progress in the therapy of advanced TNBC,but huge unmet needs exist for further therapeutic optimization.Echoing advocacy from The Society of Breast Cancer China Anti-Cancer Association;International Medical Exchange Society,China Anti-Cancer Association;Breast Cancer Group,Branch of Oncologist,Chinese Medical Doctor Association,top experts from multidisciplinary departments of breast cancer in China have consensus on this"Guidelines for clinical diagnosis and treatment of advanced triple-negative breast cancer in China(2024 edition)"according to the latest evidence based updates.We hope this pater can guide or optimize the precise therapeutic decision-making for advanced triple-negative breast cancer in China.
作者
中国抗癌协会乳腺癌专业委员会
中国抗癌协会国际医疗交流分会
中国医师协会肿瘤医师分会乳腺癌学组
袁芃
徐兵河
岳健
The Society of Breast Cancer China Anti-Cancer A.ssociation;International Medical Exchange Soclety,China Anti-Cancer Association;Breast Cancer Group,Bronch of Oncologist,Chinese Medical Doctor Association;Yuan Peng;Xu Binghe(不详;Department of VIP Medical Services,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Clinical Trials Center,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2024年第6期471-480,共10页
Chinese Journal of Oncology
基金
国家自然科学基金(82172650)。
关键词
乳腺肿瘤
晚期三阴性乳腺癌
诊断
治疗
指南
Breast neoplasms
Advanced triple-negative breast cancer
Diagnosis
Therapy
Guideline
作者简介
通信作者:袁芃,国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院特需医疗部,北京100021,Email:yuanpeng01@hotmail.com;通信作者:徐兵河,国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院药物临床试验研究中心,北京100021,Email:bhxu@hotmail.com;执笔:岳健、袁芃。
