摘要
目的:探究芳香疗法联合穴位按摩在缓解顺铂化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)中的应用。方法:本研究为一项非随机对照的类试验研究,采用便利抽样法选取2022年1月至2023年6月我院顺铂+紫杉醇方案(TP方案)化疗的非小细胞肺癌患者为研究对象。将2022年1月~6月化疗的50例非小细胞肺癌患者作为对照组,采用标准止吐方案干预,将2022年7月~12月化疗的50例非小细胞肺癌患者作为芳香组,在标准止吐方案基础上给予芳香疗法吸入干预,将2023年1月~6月化疗的50例非小细胞肺癌患者作为联合组,在标准止吐方案基础上给予芳香疗法联合穴位按摩,比较3组患者急性期(化疗用药24 h内)与延迟期恶心级别、呕吐缓解率及经济成本、护理用时的差异。结果:联合组急性期与延迟性CINV发生率及发生程度均在3组中最低,但3组急性期恶心发生率、发生程度差异无统计学意义(χ^(2)=5.178,P=0.075;Z=5.874,P=0.053),呕吐发生率、发生程度差异有统计学意义(P<0.05)。联合组第2天及第3天的恶心、呕吐发生率及发生程度均最低,3组比较差异均有统计学意义(P<0.05);两两比较显示,联合组、芳香组急性期恶心、呕吐发生率均显著低于对照组(P<0.05),且联合组延迟性恶心、呕吐发生也显著低于对照组(P<0.05),而芳香组与联合组的两两比较,差异均无统计学意义(P>0.05)。联合组生活质量评分最高,其次为芳香组,3组生活质量评分差异有统计学意义(F=8.268,P<0.001),但联合组与芳香组生活质量评分的差异无统计学意义(t=1.890,P=0.062)。联合组的护理成本与护理用时均高于芳香组。结论:芳香疗法可有效减轻急性期CINV症状,而芳香疗法联合穴位按摩不仅能够进一步减轻急性期CINV症状,还可改善延迟性CINV症状,提高患者生活质量,但需要更多的护理用时与费用。提示芳香疗法联合穴位按摩可作为非药物方法控制CINV症状,临床医护人员可在考虑护理用时和费用的情况下选择该干预措施作为辅助疗法。
Objective:To explore the applieation of aromatherapy combined with acupoint massage in aleviating chemo-therapy-induced nausea and vomiting(CINV).Methods:In this non-randomized controlled quasi-experimental study。we se-lected patients with non-small cell lung cancer treated by chemotherapy regimen of cisplatin and paclitaxel(TP regimen)in our hospital from January 2022 to June 2023 by convenience sampling as the research objects.Fifty patients with non-small cell lung cancer who received chemotherapy from January 2022 to June 2022 were treated with standard antiemetic regimen(control group).Another 50 patients with nonsmall cell lung cancer who received chemotherapy from June 2022 to December 2022 were treated with aromatherapy inhalation on the basis of the standard antiemetic regimen(the aromatherapy group).A total of 50 patients who received chemotherapy from January 2023 to June 2023 were selected as the combination group.They were given aromatherapy combined with acupoint massage on the basis of the standard antiemetic regimen.Then the nausea level,vomiting remission rate,economic cost and nursing time in three groups were compared.Results:The incidence and degree of acute and delayed CINV in the combination group were the lowest among the three groups,but there were no significant differences in the incidence and degree of acute nausea(within 24 hours of chemotherapy)among the three groups(χ^(2)=5.178,P=0.075;Z=5.874,P=0.053).There were significant differences in the incidence and degree of vomiting among the three groups(P<0.05).The incidence and degree of nausea and vomiting in the combination group were the lowest on the second and third day,and the differences among the three groups was statistically significant(P<0.05).The results of pairwise comparison showed that the incidences of acute nausea and vomiting in the combination group and the aromatherapy group were significantly lower than that in the control group(P<0.05).The incidences of delayed nausea and vomiting in the combination group were also significantly lower than that in the control group(P<0.05).However,there were no significant differences between the aromatherapy group and the combination group(P>0.05).The quality of life score of the combination group was the highest,fllowed by the aromatherapy group.The difference in quality of life scores among the three groups was statistically significant(F=8.268,P<0.001),but there was no significant difference in quality of life scores between the combination group and the aromatherapy group(t=1.890,P=0.062).The nursing cost and nursing time in the combination group were higher than those in the aromatherapy group.Conclusion:Aromatherapy can effectively reduce the symptoms of acute CINV,and aromatherapy combined with acupoint massage can not only further reduce the symptoms of acute CINV,but also alleviate the symptoms of delayed CINV and improve the quality of life of patients,but more nursing time and cost are needed.It is suggested that aromatherapy combined with acupoint massage can be used as a non-drug method to control CINV symptoms.Clinical medical staff can choose this intervention as an adjuvant therapy while considering time and cost of nursing.
作者
刘敏
汪猛
翟笑枫
徐杨
徐晓婉
Liu Min;Wang Meng;Zhai Xiaofeng;XuYang;Xu Xiaowan(Department of Traditional Chinese Medicine and Cancer,First Afiliated Hospital of Naval Medical University,Shanghai 200433,China)
出处
《肿瘤预防与治疗》
2024年第6期484-491,共8页
Journal of Cancer Control And Treatment
基金
国家自然科学基金(编号:82305339)。
关键词
芳香疗法
穴位按摩
顺铂
化疗
恶心
呕吐
Aromatherapy
Acupoint massage
Cisplatin
Chemotherapy
Nausea
Vomiting
作者简介
通讯作者:徐晓婉,E-mail:15026578846@139.com。
