摘要
目的了解EB病毒感染急性淋巴细胞白血病(ALL)患儿的临床特征,为临床干预提供参考。方法选取2020年1月—2022年8月河北省儿童医院90例≤17岁ALL住院患儿,根据是否感染EB病毒分为感染组(78例)和未感染组(12例)。收集所有患儿临床资料,采用酶联免疫吸附试验检测患儿血清EB病毒抗体谱[抗EB病毒衣壳抗体IgM(EBV-CAIgM)、抗EB病毒早期抗体IgG(EBV-EAIgG)、抗EB病毒衣壳抗体IgG(EBV-CAIgG)、抗EB病毒核抗体IgG(EBV-NA1IgG)]。比较2组患儿临床特征和各项指标差异。结果感染组和未感染组性别、年龄差异均无统计学意义(P>0.05)。急性T淋巴细胞白血病(T-ALL)患儿中EB病毒感染占70.59%(12/17),急性B淋巴细胞白血病(B-ALL)患儿中,EB病毒感染占90.41%(66/73),不同免疫分型患儿EB病毒感染所占比例差异无统计学意义(P>0.05)。B-ALL患儿和T-ALL患儿既往感染所占比例均较高(>45%)。结论ALL患儿EB病毒既往感染比例较高,临床应加强对ALL患儿EB病毒的筛查和监测。
Objective To investigate the clinical characteristics of children with acute lymphoblastic leukemia(ALL)infected by Epstein-Barr(EB)virus,and to provide a reference for clinical intervention.Method A total of 90 ALL children aged≤17 years hospitalized in Hebei Children's Hospital from January 2020 to August 2022 were enrolled and classified into infected group(78 cases)and uninfected group(12 cases)according to whether they were infected with EB virus.The clinical data of 2 groups of children were collected.Serum EB virus antibody profile[anti-EB virus capsid antibody IgM(EBV-CAIgM),anti-EB virus early antibody IgG(EBV-EAIgG),anti-EB virus capsid antibody IgG(EBV-CAIgG),anti-EB virus nuclear antibody IgG(EBV-NA1IgG)]was determined by enzyme-linked immunosorbent assay.The clinical characteristics and various indexes of the 2 groups were compared.Results There was no statistical significance in gender and age between infected and uninfected groups(P>0.05).Among children with T-acute lymphoblastic leukemia(T-ALL),70.59%(12/17)cases were infected with EB virus,while among children with B-acute lymphoblastic leukemia(B-ALL),90.41%(66/73)cases were infected with EB virus.The difference in the proportion of EB virus infection between children with different immunophenotypes was not statistically significant(P>0.05).The proportions of previous infections among children with B-ALL and T-ALL were high(>45%).Conclusions The proportion of EB virus infection in children with ALL is high.Clinical screening and monitoring of EB virus infection in ALL patients should be strengthened.
作者
闫江泓
王乐
马琳
杨硕
郭巍巍
赵梦川
刘泽昊
翟小颖
YAN Jianghong;WANG Le;MA Lin;YANG Shuo;GUO Weiwei;ZHAO Mengchuan;LIU Zehao;ZHAI Xiaoying(Institute of Pediatrics,Hebei Children's Hospital,Shijiazhuang 050000,Hebei,China;Department of Pathology,Hebei Children's Hospital,Shijiazhuang 050000,Hebei,China;Department of Clinical Laboratory,Hebei Children's Hospital,Shijiazhuang 050000,Hebei,China;Department of Hematology and Oncology,Hebei Children's Hospital,Shijiazhuang 050000,Hebei,China)
出处
《检验医学》
CAS
2024年第6期583-586,共4页
Laboratory Medicine
基金
2021年河北省医学科学研究计划(20210749)。
关键词
EB病毒
急性淋巴细胞白血病
儿童
Epstein-Barr virus
Acute lymphoblastic leukemia
Children
作者简介
闫江泓,男,1989年生,主管检验师,主要从事临床病毒相关疾病研究;通信作者:翟小颖,E-mail:757182494@qq.com;通信作者:王乐,E-mail:luka_wl@163.com。
