摘要
目的:观察糖痹康治疗糖尿病周围神经病变的临床疗效及安全性。方法:纳入60例中医辨证为气阴两虚,血瘀脉络证的糖尿病周围神经病变患者为研究对象,按照性别相同、年龄相近、体质量指数相近、就诊时间相近、糖尿病病程相似、中医证候积分相似、密歇根糖尿病神经病变积分(MDNS)相似7个条件进行1∶1配对,共配对30对,每对患者随机分入试验组(糖痹康组)和对照组(甲钴胺组),共治疗12周。以MDNS为主要疗效指标,中医证候积分、电生理、血清神经元特异性烯醇化酶(NSE)水平、空腹血糖水平、餐后2 h血糖水平、糖化血红蛋白水平为次要疗效指标,评价糖痹康治疗糖尿病周围神经病变的临床疗效及安全性。结果:试验组患者的总有效率为83.33%(25/30),对照组患者的总有效率为53.33%(16/30);经治疗,试验组患者在改善MDNS积分、改善中医证候积分、提高双侧胫神经运动神经传导速度和感觉神经传导速度、降低血清NSE水平方面均优于对照组(P<0.05);在改善空腹血糖、餐后2 h血糖、糖化血红蛋白水平方面均无显著差异(P>0.05);两组患者在试验过程中均未发现明显不良反应。结论:糖痹康与甲钴胺相比,在改善糖尿病周围神经病变患者症状及体征、提高胫神经传导速度、降低血清NSE水平方面更有优势,且糖痹康治疗糖尿病周围神经病变无明显不良反应。
Objective:To observe the clinical efficacy and safety of Tangbikang in the treatment of diabetic peripheral neuropathy.Methods:A total of 60 patients whose Chinese medicine diagnosis was qi-yin deficiency and blood stasis syndrome were selected as the study subjects.1∶1 matching was carried out according to 7 conditions:the same gender,similar age,similar body mass index,similar time of consultation,similar course of diabetes,similar traditional Chinese medicine(TCM)syndrome scores,and similar Michigan diabetic neuropathy scores.A total of 30 pairs were paired,each pair of patients randomly assigned to the experimental group(Tangbikang group)and the control group(Methylcobalamin group),for a total of 12 weeks of treatment.With Michigan diabetes neuropathy score(MDNS)as the main therapeutic index,TCM syndrome score,electrophysiology,serum NSE level,fasting blood glucose level,2-hours postprandial blood glucose level,and glycosylated hemoglobin level as the secondary therapeutic index,the clinical efficacy and safety of Tangbikang in treating diabetic peripheral neuropathy was evaluated.Results:The total effective rate of the experimental group was 83.33%(25/30),while the total effective rate of the control group was 53.33%(16/30).After treatment,compared to the control group,the experimental group showed better improvement in MDNS score,traditional Chinese medicine syndrome score,bilateral tibial nerve motor nerve conduction velocity and sensory nerve conduction velocity,and serum NSE level(P<0.05).There was no difference in improving fasting blood glucose,2-hours postprandial blood glucose,and glycated hemoglobin levels(P>0.05).No significant adverse reactions were found during the trial in both groups of patients.Conclusion:Compared with methylcobalamin,Tangbikang is more advantageous in improving the symptoms and signs of patients with diabetic peripheral neuropathy,increasing the nerve conduction velocity of the tibial nerve,and lowering the serum NSE level,and there are no significant adverse effects in the treatment of diabetic peripheral neuropathy with Tangbikang.
作者
范庆轩
刘宁乾
陈易瑶
胡燕
孙宏峰
王晓磊
乔羽
王颖
吴淑馨
易文明
FAN Qingxuan;LIU Ningqian;CHEN Yiyao;HU Yan;SUN Hongfeng;WANG Xiaolei;QIAO Yu;WANG Ying;WU Shuxin;YI Wenming(The Second Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100078,China)
出处
《中医药导报》
2024年第6期84-88,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
北京中医药大学“名医培育计划”。
作者简介
通信作者:易文明,男,主任医师,研究方向为中医药防治糖尿病及其并发症。
