摘要
二氢槲皮素是从植物中提取的类黄酮类化合物,在自然界中分布广泛,具有抗肿瘤(肝癌、肺癌、乳腺癌、直结肠癌、胃癌、骨癌、宫颈癌)、抗炎、抗氧化、抗纤维化、抗过敏、抗细胞凋亡和抗病毒等多种药理作用。目前对二氢槲皮素在抗氧化、抗炎、抗纤维化和抗细胞凋亡方面的研究比较完善,但缺乏抗病毒和抗肿瘤方面的药理研究总结。就近年来国内外对二氢槲皮素的药理作用(尤其是抗肿瘤活性)的相关文献进行归纳总结,以期为后续研究和进一步药用开发提供依据。
Dihydroquercetin is a flavonoid compound extracted from plants and is widely distributed in nature.It has many pharmacological effects such as anti-tumor(such as liver cancer,lung cancer,breast cancer,colorectal cancer,gastric cancer,bone cancer,cervical cancer),anti-inflammatory,antioxidation,antifibrosis,antiallergy,antiapoptosis and antivirus.The existing literature on dihydroquercetin in antioxidation,anti-inflammatory,antifibrosis and antiapoptosis research is relatively perfect;however,there is a lack of summary of research on antivirus and antitumor.In this paper,the pharmacological effects of dihydroquercetin are summarized at home and abroad in recent years,especially its antitumor activity,which provides a theoretical basis for further research and further medicinal development.
作者
刘欣宇
王艳
陈大忠
LIU Xinyu;WANG Yan;CHEN Dazhong(Heilongjiang University of Chinese Medicine,Harbin 150000,China)
出处
《药物评价研究》
CAS
北大核心
2024年第5期1153-1159,共7页
Drug Evaluation Research
基金
黑龙江应用技术研究与开发计划项目(GA19C107)。
关键词
二氢槲皮素
抗肿瘤
抗氧化
抗炎
抗纤维化
抗细胞凋亡
dihydroquercetin
antitumor
antioxidation
anti-inflammatory
antifibrosis
antiapoptosis
作者简介
第一作者:刘欣宇(2000—),女,硕士研究生,研究方向为药剂学。E-mail:a25803690@163.com;通信作者:陈大忠(1970—),男,研究员,硕士研究生导师,研究方向为中药物质基础及药剂学。E-mail:cdz89@126.com。
