彩色多普勒超声联合血清妊娠相关蛋白A评估胎儿生长受限及妊娠结局的研究被引量：2

Study on the Assessment of Fetal Growth Restriction and Pregnancy Outcome by Color Doppler Ultrasound Combined with Serum Pregnancy-Associated Plasma Protein A

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摘要目的:探究彩色多普勒超声联合血清妊娠相关蛋白A(PAPP-A)评估胎儿生长受限(FGR)及妊娠结局的价值。方法:回顾性分析2021年5月至2023年5月我院就诊1465例孕早期妊娠孕妇的临床资料,患者入组后均接受彩色多普勒超声检查,并检测其血清PAPP-A。依据FGR情况将其分为受限组(n=105)和正常组(n=1360),对比两组超声检测结果和血清PAPP-A水平,经ROC曲线分析入院时超声检查、血清PAPP-A水平对FGR的预测效能。依据妊娠结局情况将生长受限组孕妇分为妊娠结局异常亚组和正常分娩亚组,对比两亚组超声检测结果和血清PAPP-A水平,经ROC曲线分析入院时超声检查、血清PAPP-A水平对孕妇妊娠结局的预测效能。结果:受限组孕妇UtA-PI、UtA-RI值均高于正常组,血清PAPP-A水平低于正常组,差异有统计学意义(P<0.05)。ROC曲线分析结果表明UtA-PI、UtA-RI值、血清PAPP-A预测FGR发生的AUC分别为0.759、0.631、0.855(P<0.05)。妊娠结局异常亚组孕妇UtA-PI、UtA-RI值均高于正常分娩亚组,血清PAPP-A水平低于正常分娩亚组,差异有统计学意义(P<0.05)。ROC曲线分析结果表明UtA-PI、UtA-RI值、血清PAPP-A预测妊娠异常结局的AUC分别为0.712、0.692、0.658(P<0.05)。结论:UtA-PI、UtA-RI值、血清PAPP-A与孕妇胎儿FGR发生密切相关,且在预测孕妇妊娠结局方面具有较高的临床价值。 Objective:To explore the value of color Doppler ultrasound combined with serum pregnancy-associated protein A(PAPP-A)on evaluating fetal growth restriction(FGR)and pregnancy outcomes.Methods:The clinical data of 1465 pregnant women in the first trimester who were admitted to our hospital were retrospectively analyzed from May 2021 to May 2023.All patients underwent color Doppler ultrasound examination after enrollment,and serum PAPP-A was detected.According to the status of FGR,the patients were divided into restricted group(n=105)and normal group(n=1360).The ultrasound examination results and serum PAPP-A level were compared between the two groups.ROC curve was used to analyze the predictive efficiency of ultrasound examination and serum PAPP-A level at admission on FGR.By means of the pregnancy outcomes,the pregnant women in growth restriction group were classified into abnormal pregnancy outcome subgroup and normal delivery subgroup,and the ultrasound results and serum PAPP-A level were compared between the two subgroups.ROC curve was applied to analyze the predictive efficiency of ultrasound examination and serum PAPP-A level at admission on pregnancy outcomes.Results:The UtA-PI and UtA-RI in restricted group were significantly higher than those in normal group while serum PAPP-A level was significantly lower than that in normal group(P<0.05).ROC curve analysis showed that the AUCs of UtA-PI,UtA-RI and serum PAPP-A for predicting FGR were 0.759,0.631 and 0.855 respectively(P<0.05).The UtA-PI and UtA-RI in abnormal pregnancy outcome subgroup were significantly higher while the level of serum PAPP-A was significantly lower compared to normal delivery subgroup(P<0.05).ROC curve analysis revealed that the AUCs of UtA-PI,UtA-RI and serum PAPP-A were 0.712,0.692 and 0.658 respectively in predicting abnormal pregnancy outcomes(P<0.05).Conclusion:UtA-PI,UtA-RI values,and serum PAPP-A are closely related to the occurrence of fetal FGR and have high clinical value on predicting the pregnancy outcomes of pregnant women.

作者孙婷婷陈云刘贤香段性梅杨红艳 SUN Tingting;CHEN Yun;LIU Xianxiang(The 901st Hospital of People's Liberation Army Joint Logistic Support Force,Anhui Hefei 230031,China)

机构地区中国人民解放军联勤保障部队第九〇一医院安徽省合肥市长丰金源医院超声科

出处《河北医学》 CAS 2024年第6期987-991,共5页 Hebei Medicine

基金 2018年度安徽省学术和科技带头人及后备人选科研活动经费资助项目,(编号:2018K159)。

关键词彩色多普勒超声血清妊娠相关蛋白A 胎儿生长受限妊娠结局 Color doppler ultrasound Serum pregnancy-associated protein A Fetal growth restriction Pregnancy outcomes

分类号 R714.5 [医药卫生—妇产科学]

作者简介通讯作者:杨红艳。