摘要
目的探讨布地奈德联合复方异丙托溴铵雾化治疗小儿支气管肺炎的临床效果。方法选取2020年5月至2023年5月于济南市济阳区新市镇卫生院内科诊治的70例支气管肺炎患儿,按照不同治疗方法分为参照组(35例)与试验组(35例)。参照组采用常规抗感染治疗,试验组在参照组基础上采用布地奈德联合复方异丙托溴铵雾化治疗。比较两组治疗效果、炎症因子水平、症状体征改善时间及不良反应总发生率。结果试验组总有效率高于参照组,差异有统计学意义(P<0.05)。治疗后,试验组C反应蛋白、转化生长因子-β1及白介素-6水平均低于参照组,差异有统计学意义(P<0.05)。试验组肺部啰音改善时间、退热时间及咳嗽改善时间均短于参照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论布地奈德联合复方异丙托溴铵雾化治疗小儿支气管肺炎的临床效果确切,可缩短症状体征改善时间,降低炎症因子水平,且具有安全性,值得临床推广应用。
Objective To investigate the clinical effect of Budesonide combined with Compound Ipratropium Bromide atomization in the treatment of bronchopneumonia in children.Methods A total of 70 children with bronchopneumonia diagnosed and treated in the Department of Internal Medicine of Xinshi Town Health Center of Jiyang District of Jinan City from May 2020 to May 2023 were selected and divided into the reference group(35 cases)and the experimental group(35 cases)according to different treatment methods.The reference group was treated with conventional anti-infective therapy,and the experimental group was treated with Budesonide combined with Compound Ipratropium Bromide atomization on the basis of the reference group.The therapeutic effect,levels of inflammatory factors,improvement time of symptoms and signs,and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the reference group,and the difference was statistically significant(P<0.05).After treatment,the levels of C-reactive protein,transforming growth factor-β1,and interleukin-6 in the experimental groups were lower than those in the reference group,and the differences were statistically significant(P<0.05).The improvement time of pulmonary rales,fever,and cough in the experimental group was shorter than that in the reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Budesonide combined with Compound Ipratropium Bromide atomization in the treatment of bronchopneumonia in children has definite clinical effect,can shorten the improvement time of symptoms and signs,reduce the levels of inflammatory factors,and has safety,which is worthy of clinical application.
作者
杨文文
YANG Wenwen(Department of Internal Medicine,Xinshi Town Health Center of Jiyang District of Jinan City,Shandong Province,Jinan 251400,China)
出处
《妇儿健康导刊》
2024年第11期54-57,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
布地奈德
复方异丙托溴铵
雾化治疗
小儿支气管肺炎
Budesonide
Compound Ipratropium Bromide
Atomization
Children with bronchopneumonia
