噻托溴铵联合沙美特罗替卡松对老年支气管哮喘患者炎性因子及不良反应的影响

Effects of tiotropium bromide combined with salmeteroticasone on inflammatory factors and adverse reactions in elderly patients with bronchial asthma

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摘要目的探讨噻托溴铵联合沙美特罗替卡松对老年支气管哮喘患者炎性因子及不良反应的影响。方法选择2021年1月-2023年1月神木市中医医院收治的100例老年支气管哮喘患者作为观察对象,根据随机数字表法将其分为对照组和研究组各50例,其中对照组采用噻托溴铵治疗,研究组采用噻托溴铵联合沙美特罗替卡松治疗,比较两组患者临床应用效果。结果经过一段时间治疗后,对照组的IL-8、IL-6及TNF-α指标均高于研究组,P<0.05;对比两组患者治疗后肺功能变化,对照组的FEV1、PEF、FVC及FEV1/FVC指标均低于研究组指标,P<0.05;比较两组患者治疗过程中不良反应的发生率,对照组不良反应总发生率为12.00%,高于研究组的4.00%,但差异不显著,P>0.05;对比两组患者治疗效果,对照组治疗总有效率为68.00%,低于研究组的90.00%,P<0.05。结论噻托溴铵联合沙美特罗替卡松治疗老年支气管哮喘效果显著,不仅降低了炎性因子水平,还有效改善了患者肺功能,且二者联合使用不良反应较低,有较高的应用价值。 Objective To investigate the effects of tiotropium bromide combined with salmeteroticasone on inflammatory factors and adverse reactions in elderly patients with bronchial asthma.Methods 100 elderly patients with bronchial asthma admitted to our hospital from January 2021 to January 2023 were selected as observation objects,and were divided into control group and study group with 50 cases each according to random number table method.The control group received tiotropium,and the study group received tiotropium bromide combined salmeterol ticasone,and the clinical effects of the two groups were compared.Results After a period of treatment,the levels of IL-8,IL-6 and TNF-αin control group were higher than those in study group(P<0.05).The pulmonary function changes of the two groups after treatment were compared,and the indexes of FEV1,PEF,FVC and FEV1/FVC in the control group were lower than those in the study group,P<0.05;the incidence of complications during treatment was compared between the two groups.The total incidence of adverse reactions in the control group was 12.00%higher than that in the study group(4.00%),P>0.05.The total effective rate of the control group was 68.00%,lower than the 90.00%of the study group,P<0.05.Conclusion Tiotropium bromide combined with salmeteroticasone is effective in the treatment of elderly bronchial asthma,not only reducing inflammatory factors,but also effectively improving lung function of patients,and the combination of the two has low adverse reactions,and has high application value.

作者张艳军杜志锋 Zhang Yanjun;Du Zhifeng(Department of the Second Internal Medicine,Shenmu Hospital of Traditional Chinese Medicine,YuLin,Shaanxi 719300,China;Department of Internal Medicine,Zhidan County People's Hospital,Yan'an,Shaanxi 717500,China)

机构地区陕西省神木市中医医院陕西省志丹县人民医院

出处《首都食品与医药》 2024年第11期73-75,共3页 Capital Food Medicine

关键词噻托溴铵沙美特罗氟替卡松老年支气管哮喘 Tiotropium bromide Salmeterol Fluticasone Senile bronchial asthma

分类号 R562.25 [医药卫生—呼吸系统]

作者简介通信作者:杜志锋,邮箱:syf22334455@163.com。