摘要
目的研究血清癌坯抗原(CEA)、降钙素原(PCT)水平在甲状腺髓样癌(MTC)根治性手术治疗前后的检查意义。方法回顾性分析2020年1月—2023年1月在西安市鄠邑区人民医院接受根治性手术治疗的80例MTC患者的临床病理数据及随访数据,分析血清CEA、PCT水平与术前病理特征关系,使用受试者工作特征曲线(ROC)分析CEA及PCT对MTC淋巴结转移的预测效能,根据术后随访情况将患者分为治愈组与复发/转移组,对比两组患者术后3个月、6个月血清CEA、PCT水平。结果术前,血清CEA、PCT水平在不同性别、年龄患者中比较,差异无统计学意义(P>0.05),但在单病灶与多病灶、肿瘤<2 cm与≥2 cm、有淋巴结转移与无淋巴结转移患者之间比较,差异具有统计学意义(P<0.05);术前血清CEA对MTC淋巴结转移的预测截断值为35.75 ng/mL,灵敏度为84.61%,特异度为72.53%;PCT对MTC淋巴结转移的预测截断值为3.65 ng/mL,灵敏度为86.52%,特异度为80.77%;随访发现复发/进展患者术后3个月、6个月血清CEA、PCT水平高于治愈患者,差异具有统计学意义(P<0.05)。结论术前血清CEA及PCT水平可以较好的反映出MTC患者肿瘤的大小、病灶数量情况,对淋巴结转移具备较好的预测能力,术后血清CEA及PCT水平可以较好反映出病情进展情况。
Objective To study the significance of serum carcinoembryonic antigen(CEA)and procalcitonin(PCT)levels before and after radical surgery for medullary thyroid carcinoma(MTC).Methods The clinicopathological data and followup data of 80 MTC patients who underwent radical surgery in our hospital from January 2020 to January 2023 were retrospectively analyzed,and the relationship between serum CEA and PCT levels and preoperative pathological characteristics was analyzed.The predictive effi cacy of CEA and PCT for MTC lymph node metastasis was analyzed by receiver operating characteristic curve(ROC).According to the postoperative follow-up,patients were divided into cure group and recurrence/metastasis group,and the serum CEA and PCT levels of the two groups were compared in March and June after operation.Results There was no signifi cant diff erence in serum CEA and PCT levels between patients of diff erent sexes and ages before operation(P>0.05),but there were signifi cant diff erences between patients with single lesion and multiple lesions,tumors<2 cm and≥2cm,and patients with and without lymph node metastasis(P<0.05).The cutoff value of preoperative serum CEA for predicting MTC lymph node metastasis was 35.75 ng/mL,with sensitivity of 84.61%and specificity of 72.53%.The cutoff value of PCT for predicting MTC lymph node metastasis is 3.65ng/mL,with sensitivity of 86.52%and specifi city of 80.77%.Follow-up showed that the serum CEA and PCT levels in patients with recurrence/progression were higher than those in patients with cure at 3 months and 6 months after operation,and the diff erence was statistically signifi cant(P<0.05).Conclusion Preoperative serum CEA and PCT levels can better reflect the tumor size and the number of lesions in MTC patients,and have a good predictive ability for lymph node metastasis,while postoperative serum CEA and PCT levels can better refl ect the progress of the disease.
作者
王娟
WANG Juan(Clinical Laboratory,Xi'an Hu Yi District People's Hospital,Xi'an Shaanxi,710300,China)
出处
《中华养生保健》
2024年第13期38-41,共4页
CHINESE HEALTH CARE
关键词
癌坯抗原
降钙素原
甲状腺髓样癌
淋巴结转移
病情进展
carcinoembryonic antigen
procalcitonin
medullary thyroid carcinoma
lymph node metastasis
disease progression
作者简介
王娟(1988-),女,汉族,籍贯:陕西省西安市,本科,主管检验师,研究方向:检验微生物。
