摘要
目的分析急性脑梗死患者溶栓治疗后再入院的影响因素。方法回顾性选取2021年6月—2022年6月湖北省京山市人民医院进行溶栓治疗的100例急性脑梗死患者的临床资料,根据其治疗后1年内是否再入院分为再入院组(26例)和未入院组(74例)。进行单因素和多因素Logistic回归分析急性脑梗死患者溶栓治疗后再入院的影响因素。结果单因素分析:两组的年龄、高血糖病史、发病至溶栓时间、梗死灶直径、入院时美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、血清转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、白细胞介素-10(Interleukin-10,IL-10)和肿瘤坏死因子(Tumor Ne-crosis Factor,TNF-α)水平比较,差异有统计学意义(P均<0.05);多因素分析:年龄(OR=1.345)、合并高血糖(OR=1.034)、发病至溶栓时间≥3 h(OR=3.536)、梗死灶直径≥4.6 cm(OR=2.584)、入院时NIHSS评分(OR=2.167)、IL-10(OR=1.473)、TNF-α水平(OR=1.042)是影响急性脑梗死患者再入院中的独立危险因素,TGF-β1(OR=0.657)水平是急性脑梗死患者再入院中的独立保护因素(P均<0.05)。结论年龄、合并高血糖、发病至溶栓时间、梗死灶直径、入院时NIHSS、IL-10、TNF-α水平是影响急性脑梗死患者再入院的危险因素,而TGF-β1水平是急性脑梗死患者再入院的保护因素,为临床治疗该类疾病提供依据。
Objective To analyze the influencing factors of readmitted hospital admission in patients with acute cerebral infarction after thrombolytic therapy.Methods The clinical data of 100 patients with acute cerebral infarction who underwent thrombolytic therapy in Jingshan People's Hospital of Hubei Province from June 2021 to June 2022 were retrospectively selected.They were divided into readmission group(26 cases)and non-readmission group(74 cases)according to whether they were readmitted within 1 year after treatment.All patients had been treated with thrombolysis.Univariate and multivariate Logistic regression were performed to analyze the influencing factors of readmission in patients with acute cerebral infarction after thrombolytic therapy.Results Single factor analysis:there were statistically significant differences in age,history of hyperglycemia,time from onset to thrombolysis,infarct diameter,National Institute of Health Stroke Scale(NIHSS)scores,transforming growth factor-β1(TGF-β1),interleukin-10(IL-10)and tumor necrosis factor(TNFα)levels at admission between the two groups(all P<0.05).Multi-factor analysis:age(OR=1.345),combined hyperglycemia(OR=1.034),time from onset to thrombolysis≥3 h(OR=3.536),infarct diameter≥4.6 cm(OR=2.584),NIHSS scores(OR=2.167),IL-10(OR=1.473)and TNF-αlevel(OR=1.042)were independent risk factors for readmitted patients with acute cerebral infarction,and TGF-β1(OR=0.657)level was an independent protective factor for readmission in patients with acute cerebral infarction(all P<0.05).Conclusion Age,combined hyperglycemia,time from onset to thrombolysis,infarct diameter,NIHSS,IL-10 and TNF-αlevels at admission were risk factors for readmitted hospital admission in patients with acute cerebral infarction,while TGF-β1 level was a protective factor for readmitted hospital admission in patients with acute cerebral infarction,providing a basis for clinical treatment of this disease。
作者
谭诗云
曾小容
程少先
TAN Shiyun;ZENG Xiaorong;CHENG Shaoxian(Department of Neurology,Jingshan People's Hospital,Jingshan,Hubei Province,431899 China;Department of General SurgeryⅡ,Jingshan People's Hospital,Jingshan,Hubei Province,431899 China)
出处
《系统医学》
2024年第9期112-115,共4页
Systems Medicine
基金
荆门市引导性科研计划(2023YDKY104)。
关键词
急性脑梗死
溶栓治疗
独立危险因素
炎症因子
Acute cerebral infarction
Thrombolytic therapy
Independent risk factors
Inflammatory factor
作者简介
谭诗云(1989-),女,本科,主要从事重症监护和心理护理工作;通信作者:程少先(1983-),男,本科,副主任医师,主要从事胸部肿瘤的临床和基础研究工作,E-mail:282009600@qq.com。
