摘要
目的探讨神经元特异性烯醇化酶(NSE)和脑钠肽在中老年基底节区出血病人预后评估中的应用价值。方法选择2020年1月至2022年12月在安徽医科大学附属滁州医院治疗的85例中老年基底节区出血病人进行回顾性分析,根据病人发病后3个月的改良Rankin量表(mRS)评分,将病人分为预后良好组和预后不良组,利用受试者操作特征曲线(ROC曲线)和logistic回归分析评估NSE和脑钠肽的预后价值。结果预后良好组中NSE(13.67±4.51)µg/L明显低于预后不良组(18.36±6.52)µg/L(P<0.001),预后良好组中脑钠肽143.00(98.00,233.80)ng/L明显低于预后不良组230.00(120.00,400.00)ng/L(P=0.002)。ROC曲线显示NSE和脑钠肽的最佳截取值分别为15.5µg/L和156.5 ng/L。NSE联合脑钠肽时AUC为0.76,与二者单独应用时的0.73、0.70差异无统计学意义。logistic回归分析显示出血量(P=0.017)、NSE(P=0.003)和脑钠肽(P=0.033)是影响病人预后的独立危险因素。结论NSE和脑钠肽在中老年基底节区出血病人的短期预后评估中具有重要价值,值得进一步研究。
Objective To explore the application value of neuron-specific enolase(NSE)and brain natriuretic peptide in prognostic evaluation of middle-aged and elderly patients with basal ganglia area hemorrhage.Methods The clinical data of 85 middle-aged and older patients with basal ganglia area hemorrhage treated in The Affiliated Chuzhou Hospital of Anhui Medical University from January 2020 to December 2022 were retrospectively analyzed.According to the modified Rankin Scale(mRS)scoring three months after onset,the patients were assigned into good prognosis group and poor prognosis group.Receiver operating characteristic(ROC)curve and logistic regression analysis were used to evaluate the prognostic value of NSE and brain natriuretic peptide.Results The NSE concentration in the good prognosis group was significantly lower than that in the poor prognosis group[(13.67±4.51)μg/L vs.(18.36±6.52)μg/L,P<0.001].The level of brain natriuretic peptide in the good prognosis group was significantly lower than that in the poor prognosis group [143.00 (98.00, 233.80) ng/L vs. 230.00(120.00,400.00)ng/L, P = 0.002]. ROC curve showed that the optimal cutoff values of NSE and brain natriuretic peptide were 15.5 μg/L and 156.5 ng/L respectively. The AUC of NSE combined with brain natri uretic peptide was 0.76, which was higher than that for individual use (0.73, 0.70, respectively), but the difference was not statistically significant. Logistic regression analysis results showed that blood loss (P = 0.017), NSE (P = 0.003) and brain natriuretic peptide (P = 0.033) were independent risk factors affecting the prognosis of patients.Conclusion NSE and brain natriuretic peptide have impor tant value in the short-term prognostic evaluation of middle-aged and elderly patients with basal ganglia area hemorrhage, which de serves further study.
作者
高华祝
侯仕强
邵尉
周冬瑞
姚国权
石碑田
GAO Huazhu;HOU Shiqiang;SHAO Wei;ZHOU Dongrui;YAO Guoquan;SHI Beitian(Department of Neurosurgery,The Affiliated Chuzhou Hospital of Anhui Medical University,The First People´s Hospital of Chuzhou,Chuzhou,Anhui 239000,China)
出处
《安徽医药》
CAS
2024年第7期1417-1420,共4页
Anhui Medical and Pharmaceutical Journal
基金
安徽省高校自然科学研究重点项目(2022AH050769)。
关键词
脑血管基底神经节出血
神经元特异性烯醇化酶
脑钠肽
中老年
预后
Basal ganglia hemorrhage
Neuron-specific enolase(NSE)
Brain natriuretic peptide(BNP)
Middle-aged and older
Prognosis
作者简介
通信作者:石碑田,男,副主任医师,研究方向为脑血管病及颅内肿瘤的临床与基础,Email:shibeitian1351@163.com。
