摘要
目的研究山豆根药材、饮片、标准汤剂、配方颗粒的主要成分检测方法,为山豆根配方颗粒的应用提供参考。方法通过高效液相色谱建立山豆根药材、饮片、标准汤剂、配方颗粒指纹图谱检测方法,利用相似度评价、相关性分析、聚类分析及主成分分析进行评价和分析。结果山豆根药材、饮片、标准汤剂和配方颗粒的指纹图谱色谱中均有5个共有特征峰,且全部指认;相似度评价及化学模式识别研究表明四者无明显的差异。结论山豆根药材、饮片、标准汤剂和配方颗粒的主要组成成分基本一致,可为山豆根配方颗粒的基础研究及临床应用研究提供参考。
Objective To study the detection methods of main components in medicinal materials,decoction pieces,standard decoction and formula granules of Radix Sophorae Tonkinensis,so as to provide reference for the application of Radix Sophorae Tonkinensis formula granules.Methods HPLC was used to establish a fingerprint detection method for medicinal materials,decoction pieces,standard decoction and formula granules of Radix Sophorae Tonkinensis,and similarity evaluation,correlation analysis,cluster analysis and main component analysis were used for evaluation and analysis.Results There were five common characteristic peaks in the fingerprint chromatograms for medicinal materials,decoction pieces,standard decoction and formula granules of Radix Sophorae Tonkinensis,all of which were identified.Similarity evaluation and chemical pattern recognition research showed that there was no obvious difference between the four kinds.Conclusion The main components of medicinal materials,decoction pieces,standard decoction and formula granules of Radix Sophorae Tonkinensis are basically the same,which can provide reference for the basic research and clinical application research for formula granules of Radix Sophorae Tonkinensis.
作者
游庭活
赵伟志
陈周全
张辉
段康
张莉梅
YOU Tinghuo;ZHAO Weizhi;CHEN Zhouquan;ZHANG Hui;DUAN Kang;ZHANG Limei(China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co.,Ltd.,Guangdong,Huizhou 516000,China;China Resources Sanjiu Pharmaceutical Co.,Ltd.,Guangdong,Shenzhen 518110,China)
出处
《中国医药科学》
2024年第9期13-17,共5页
China Medicine And Pharmacy
基金
广东省深圳市科技计划项目(JSGG20191129093418578)。
关键词
山豆根
标准汤剂
指纹图谱
配方颗粒
化学模式识别
Radix Sophorae Tonkinensis
Standard decoction
Fingerprint
Formula granules
Chemical pattern recognition
作者简介
通讯作者:张莉梅。
