摘要
目的研究纤维蛋白(原)降解产物(fibrin degradation product,FDP)水平与肝移植术后胆道并发症(biliary complications,BC)发生之间的潜在关系,总结BC发生的相关危险因素。方法回顾性分析2015年1月—2022年7月陆军军医大学第一附属医院和四川省人民医院491例肝移植的人口统计学资料、临床指标和预后随访信息。采用重叠加权(overlap weighting,OW)平衡各组患者中的混杂因素。利用接受者操作特性(receiver operating characteristic,ROC)曲线来确定FDP的最佳临界值。Logistic回归模型分析影响预后的危险因素。结果491例患者中79例(16.1%)发生BC。OW后多因素Logistic回归结果显示,FDP>10.65 mg/L、MELD评分>15分为术后BC发生的独立危险因素(均P<0.05)。结论高水平的FDP对BC发生风险有显著影响,FDP>10.65mg/L为BC发生的独立危险因素。
Objective To investigate the potential relationship between fibrin degradation product(FDP)levels and the development of biliary complications(BC)after liver transplantation,and to summarize the risk factors associated with the development of BC.Methods A retrospective cohort study was conducted in patients undergoing liver transplantation from January 2015 to July 2022 in the Southwest Hospital,Army Medical University and Sichuan Provincial People's Hospital.Demographic data,clinical indicators,and prognostic follow-up information of patients were analyzed.Overlap weighting(OW)was used to reduce bias.Receiver operating characteristic(ROC)curves were applied to define the cutoff value of FDP.The value divided patients into high-and low-FDP groups.Logistic regression identified risk factors.Results A total number of 491 patients were enrolled,and 79(16.1%)suffered from BC.Multivariable logistic regression revealed that FDP>10.65 mg/L and MELD score>15 were associated with BCs after OW.Conclusion High FDP had significant effect on the risk of BC occurrence and FDP>10.65 mg/L was an independent risk factor for BC.
作者
潘比
黄译贤
欧晏娇
张城城
刘炜
刘兴超
张雷达
Pan Bi;Huang Yixian;Ou Yanjiao;Zhang Chengcheng;Liu Wei;Liu Xingchao;Zhang Leida(Department of Hepatobiliary Surgery,Southwest Hospital,Army Medical University,Chongqing 400038,China;Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 610000,Sichuan,China.)
出处
《实用器官移植电子杂志》
2024年第3期215-219,共5页
Practical Journal of Organ Transplantation(Electronic Version)
基金
重庆市科技局技术创新与应用发展(CSTB2022TIAD-GPX0086)。
关键词
肝移植
胆道并发症
纤维蛋白(原)降解产物
重叠加权
Liver transplantation
Biliary complication
Fibrin degradation product
Overlap weighting
作者简介
通讯作者:张雷达,Email:zldxngd@163.com。
