摘要
目的 探讨双表型原发性肝细胞癌的治疗效果。方法 选取2020年3月—2022年3月福建医科大学孟超肝胆医院诊治的1 151例原发性肝细胞癌患者为研究对象。按照病理分型进行分组,分为对照组(非双表型原发性肝细胞癌,共575例)与研究组(双表型原发性肝细胞癌,共576例),2组均接受腹腔镜肝切除术或开放手术治疗。对比2组的生存情况与血清生化指标。结果 研究组生存时间为(2.14±0.23)年,短于对照组的(3.96±1.02)年;研究组1、3、5年生存率低于对照组(P<0.05)。研究组甲胎蛋白(alpha-fetoprotein,AFP)、总胆红素(total bilirubin,TBIL)、血清白蛋白(albumin,ALB)高于对照组,谷氨酰转移酶(glutamyltransferase,GGT)、碱性磷酸酶(alkaline phosphatase,ALP)、血小板(platelet,PLT)低于对照组,差异有统计学意义(P<0.05)。结论 相较于非双表型原发性肝细胞癌,双表型原发性肝细胞癌的恶性度更高,生存时间更短,预后效果更差。
Objective To explore the therapeutic effect of biphenotypic primary hepatocellular carcinoma.Methods A total of 1151 patients with primary hepatocellular carcinoma diagnosed and treated in Mengchao Hepatobiliary Hospital of Fujian Medical University from March 2020 to March 2022 were selected as the study objects.According to the pathological classification,they were divided into the control group(non-biphenotypic primary hepatocellular carcinoma,575 cases)and the study group(biphenotypic primary hepatocellular carcinoma,576 cases).Both groups were treated with laparoscopic hepatectomy or open surgery.The survival and serum biochemical indexes of the two groups were compared.Results The survival time of the study group was(2.14±0.23)years,shorter than that of the control group(3.96±1.02)years.The 1,3 and 5-year survival rates of the study group were lower than those of the control group(P<0.05).Alpha-fetoprotein(AFP),total bilirubin(TBIL)and albumin(ALB)of the study group were higher than those of the control group,while glutamyltransferase(GGT),alkaline phosphatase(ALP)and platelet(PLT)of the study group were lower than those of the control group,with statistical significance(P<0.05).Conclusion Compared with non-biphenotypic hepatocellular carcinoma,biphenotypic hepatocellular carcinoma has higher malignant degree,shorter survival time,and worse prognosis.
作者
刘腾
曾建兴
吕嘉晖
LIU Teng;ZENG Jianxing;LYU Jiahui(Department of Hepatobiliary Surgery,Mengchao Hepatobiliary Hospital of Fujian Medical University,Fuzhou Fujian 350001,China)
出处
《中国卫生标准管理》
2024年第10期116-119,共4页
China Health Standard Management
关键词
双表型原发性肝细胞癌
外科手术治疗
血清生化指标
生存时间
生存率
预后
biphenotypic primary hepatocellular carcinoma
surgical treatment
serum biochemical index
survival time
survival rate
prognosis
