摘要
目的研讨妇科盆腔炎性疾病采用喹诺酮类抗菌药治疗的效果。方法选取60例妇科盆腔炎性疾病患者,经抽签法分组模式将患者分为对照组和研究组,每组30例。对照组采用中成药治疗,研究组在对照组基础上进行喹诺酮类抗菌药治疗。比较两组体征与症状评分、治疗效果及炎性因子[C反应蛋白(CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果两组治疗前高热、腹部疼痛、小腹坠胀、尿道炎症、白带异常、月经失调、精神不振、疲惫无力、失眠评分不具有差异性(P>0.05);治疗后研究组高热、腹部疼痛、小腹坠胀、尿道炎症、白带异常、月经失调、精神不振、疲惫无力、失眠评分均低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率96.67%较对照组的76.67%更高(P<0.05)。研究组治疗后CRP(16.38±9.80)mg/L、IL-1(61.29±11.31)pg/ml、TNF-α(39.42±10.75)pg/ml、IL-6(63.47±10.25)pg/ml低于对照组的(23.77±9.45)mg/L、(72.37±11.20)pg/ml、(50.59±10.80)pg/ml、(70.85±10.37)pg/ml,差异有统计学意义(P<0.05)。结论喹诺酮类抗菌药应用于妇科盆腔炎性疾病中可提升治疗效果,降低炎性因子水平,改善体征与症状。
Objective To explore the effect of quinolone antibiotics in the clinical treatment of gynecological pelvic inflammatory diseases.Methods 60 patients with gynecological pelvic inflammatory disease were selected.They were divided into a control group and a study group by lottery method,with 30 patients in each group.The control group was treated with traditional Chinese patent medicines,and the study group was treated with quinolone antibiotics based on the control group.The symptoms and sign score,treatment effect,inflammatory factors[C-reactive protein(CRP),interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]of the two groups were compared.Results Before treatment,there were no differences in scores of high fever,abdominal pain,lower abdominal distension,urethral inflammation,abnormal leucorrhea,menstrual disorder,lethargy,fatigue and insomnia between the two groups(P>0.05).After treatment,the scores of high fever,abdominal pain,lower abdominal distension,urethral inflammation,abnormal leucorrhea,menstrual disorder,lethargy,fatigue and insomnia in the study group were lower than those in the control group,with a statistically significant difference(P<0.05).The total effective rate of the study group was 96.67%,which was higher than 76.67% of the control group(P<0.05).After treatment,the study group had CRP of(16.38±9.80)mg/L,IL-1 of(61.29±11.31)pg/ml,TNF-αof(39.42±10.75)pg/ml,and IL-6 of(63.47±10.25)pg/ml,which were lower than(23.77±9.45)mg/L,(72.37±11.20)pg/ml,(50.59±10.80)pg/ml,and(70.85±10.37)pg/ml in the control group,with a statistically significant difference(P<0.05).Conclusion The application of quinolone antibiotics in gynecological pelvic inflammatory diseases can improve the treatment effect,reduce the level of inflammatory factors,and improve the signs and symptoms.
作者
王蒙
杨晨
王宜芹
WANG Meng;YANG Chen;WANG Yi-qin(Department of Gynecology and Obstetrics,Rizhao Maternal and Child Health Hospital,Rizhao 276827,China)
出处
《中国现代药物应用》
2024年第9期9-12,共4页
Chinese Journal of Modern Drug Application
关键词
妇科
盆腔炎性疾病
喹诺酮
左氧氟沙星
Gynecology
Pelvic inflammatory disease
Quinolone
Levofloxacin
