摘要
目的 分析枞阳县艾滋病病毒感染者及艾滋病病人(HIV/AIDS)接受抗逆转录病毒治疗(ART)后病毒抑制效果及相关影响因素。方法 收集枞阳县接受ART6个月以上HIV/AIDS数据资料进行回顾性分析,采用χ^(2)检验、Fisher确切概率法及二分类logistic回归模型分析ART患者病毒抑制失败影响因素。结果 211例HIV/AIDS治疗后首次病毒载量≥1 000 copies/m L者15例,病毒抑制失败率为7.11%。单因素分析显示,不同婚姻状况、文化程度、有无漏服药、HIV抗体确证距离治疗时间及家人支持情况组间病毒抑制差异有统计学意义(P<0.05)。多因素分析显示,以ART成功为对照,无漏服药(OR=0.189,95%CI:0.039~0.919)是病毒抑制失败的保护因素,文化程度小学及以下(OR=12.252,95%CI:1.611~93.175)、家人歧视/不知情(OR=11.964,95%CI:2.520~56.799)是病毒抑制失败的危险因素。结论 有无漏服药、文化程度、家人支持情况是ART患者病毒抑制失败的影响因素,应加强依从性教育及家庭支持系统以提高抗病毒治疗病毒抑制成功率。
Objective To analyze the virus suppression effect and related influencing factors of HIV infections and AIDS patients(HIV/AIDS)receiving antiretroviral therapy(ART)in Zongyang County.Methods The data of HIV/AIDS pa-tients who had received ART for more than 6 months in Zongyang County were collected for retrospective analysis.The Chi-squared test,Fisher exact probability method and binary logistic regression model were used to analyze the influencing fac-tors of viral inhibition failure in ART patients.Results Among 211 HIV/AIDS patients,15 cases had viral load≥1000 copies/mL for the first time after treatment,and the failure rate of virus inhibition was 7.11%.Univariate analysis showed that there were statistically significant differences in virus suppression among groups with different marital status,educational level,missed medication,HIV antibody confirmation,treatment time,and family support(P<0.05).Multivariate analysis showed that,with successful antiviral treatment as the control,no missed medication(OR=0.189,95%CI:0.039-0.919)was a protective factor for viral inhibition failure,while education level of primary school or below(OR=12.252,95%CI:1.611-93.175)and family discrimination/lack of knowledge(0R=11.964,95%CI:2.520-56.799)were risk factors for viral inhibition failure.Conclusion The factors affecting the failure of viral suppression in ART patients include missed medication,educational level,and family support.Compliance education and family support systems should be strengthened to improve the success rate of viral suppression in antiviral treatment.
作者
陶爽飞
张友为
TAO Shuangfei;ZHANG Youwei(Zongyang County Center for Disease Control and Prevention,Tongling 246702,Anhui,China)
出处
《安徽预防医学杂志》
2024年第1期11-14,33,共5页
Anhui Journal of Preventive Medicine
作者简介
陶爽飞(1973-),男,副主任医师,本科,主要从事艾滋病性病防治工作。
