摘要
目的了解济南市急性脑炎脑膜炎症候群(Acute meningitis and encephalitis syndrome,AMES)监测病例病原谱构成。方法2017-2021年在济南市7家医院开展AMES病例监测,采集血清和/或脑脊液标本,检测乙型脑炎病毒(Japanese encephalitis virus,JEV)、肠道病毒(Enterovirus,EV)、流行性腮腺炎病毒(Mumps virus,MuV)和单纯疱疹病毒(Herpes simplex virus,HSV)IgM抗体以及脑膜炎奈瑟菌(Neisseria meningitides,Nm)、肺炎链球菌(Streptococcus pneumoniae,Spn)和b型流感嗜血杆菌(Haemophilus influenza type b,Hib)抗原,分析IgM抗体和抗原阳性率。结果AMES病例JEV、EV、MuV、HSV IgM抗体阳性率分别为3.15%(82/2604)、13.62%(298/2188)、10.92%(239/2188)、4.94%(108/2188),其中最高年龄别阳性率分别为7.61%(≥40岁)、30.09%(5-9岁)、16.52%(5-9岁)、7.16%(≥40岁);Nm、Spn、Hib抗原阳性率分别为2.07%(50/2420)、1.03%(25/2420)、0.08%(2/2420),其中最高年龄别阳性率分别为4.65%(25-29岁)、2.56%(20-24岁)、0.17%(≥40岁)。在Nm抗原阳性病例中B群病例占44%(22/50)。结论济南市2017-2021年AMES病例优势病原为EV、MuV、HSV和JEV。建议加强儿童EV和MuV免疫预防,开展≥40岁人群乙脑疫苗接种,加快B群Nm疫苗研发和应用。
Objective To determine the spectrum of pathogens of acute meningitis and encephalitis syndrome(AMES)cases in Jinan city.Methods We collected serum and/or cerebrospinal fluid samples of AMES cases in seven sentinel hospitals of Jinan during 2017-2021.We tested for Japanese encephalitis virus(JEV),enterovirus(EV),mumps virus(MuV),and herpes simplex virus(HSV)IgM antibodies and Neisseria meningitides(Nm),Streptococcus pneumonia(Spn),and Haemophilus influenza type b(Hib)antigens to determine positivity rates.Results Prevalences of JEV,EV,MuV,and HSV IgM antibodies were 3.15%(82/2604),13.62%(298/2188),10.92%(239/2188),and 4.94%(108/2188),respectively,with the highest age-specific positivity rates being 7.61%in≥40-year-olds,30.09% in 5-9-year-olds,16.52% in 5-9-year-olds,and 7.16%in≥40-year-olds.Positivity rates of Nm,Spn,and Hib antigens were 2.07%(50/2420),1.03%(25/2420),and 0.08%(2/2420),with the highest age-specific positivity rates being 4.65%in 25-29-year-olds,2.56%in 20-24-year-olds,and 0.17% in≥40-year-olds.Group B Nm cases accounted for 44%(22/50)of Nm antigen positive cases.Conclusions The dominant AMES pathogens in Jinan during 2017-2021 were EV,MuV,HSV,and JEV.We should strengthen childhood EV and MuV vaccination,conduct JEV vaccination of≥40-year-olds,and accelerate group B Nm vaccine research,development,and use.
作者
武晶晶
刘子薇
谭丽
杨风华
孙红云
Wu Jingjing;Liu Ziwei;Tan Li;Yang Fenghua;Sun Hongyun(Jinan Municipal Center for Disease Control and Prevention,Jinan 250021,Shandong,China;Pingyin County Center for Disease Control and Prevention,Jinan 250400,Shandong,China)
出处
《中国疫苗和免疫》
CSCD
北大核心
2024年第2期169-173,共5页
Chinese Journal of Vaccines and Immunization
关键词
急性脑炎脑膜炎症候群
病毒
细菌
病原谱
Acute meningitis and encephalitis syndrome
Virus
Bacteria
Pathogen spectrum
作者简介
通信作者:孙红云,Email:sunhongyun@163.com;第一作者:武晶晶,Email:81938308@qq.com。
