摘要
目的分析还原型谷胱甘肽联合急诊常规治疗对急性有机磷中毒患者的疗效。方法回顾性分析2018年1月—2023年1月于本院就诊的急性有机磷中毒患者共计50例,依照治疗方式分为参比组和分析组。参比组(n=25,常规急诊治疗),分析组(n=25,常规急诊治疗+还原型谷胱甘肽治疗)。比较两组治疗效果。结果分析组治疗后临床症状转归指标(M样症状消失时间、肌酸激酶恢复时间、心肌钙蛋白恢复时间、CHE活力恢复时间)均显著短于参比组(P<0.05);分析组治疗后肝功能指标(ALT、AST、ALB)改善情况均显著优于参比组(P<0.05)。分析组治疗1d、7d后CHE活性均显著高于参比组(P<0.05)。分析组临床疗效高于参比组(P<0.05)。结论针对急性有机磷中毒患者,在常规急诊治疗基础上,联合应用还原型谷胱甘肽,有利于肝功能及CHE活性转归,可缩短临床症状转归时间,于临床疗效提升有显著增益。
Objective To analyze effect of reduced glutathione combined with emergency routine treatment for patients with acute organophosphate poisoning.Methods The paper reviewed and analyzed 50 patients with acute organophosphorus poisoning in our hospital from January 2018 to January 2023,and divided them into groups according to treatment method,including reference group(n=25,with routine emergency treatment),analysis group(n=25,with routine emergency treatment+reduced glutathione treatment).Curative effect was compared between two groups.Results Clinical symptom outcome indicators(disappearance time of M-like symptoms,recovery time of creatine kinase,recovery time of cardiac troponin,and recovery time of CHE activity)in analysis group were significantly lower than control group after treatment(P<0.05).Improvement of liver function indicators(ALT,AST,ALB)in analysis group after treatment was significantly better than control group(P<0.05).After treatment for 1 and 7 days,CHE activity in analysis group was significantly higher than control group(P<0.05).Clinical effect of analysis group was higher than control group(P<0.05).Conclusion Reduced glutathione combined with routine emergency treatment can promote liver function and CHE activity recovery,shorten clinical symptom recovery time,and improve clinical effect of patients with acute organophosphorus poisoning significantly.
作者
谢莉
董振超
张小军
王坚
XIE Li;DONG Zhenchao;ZHANG Xiaojun;WANG Jian(Danyang City People's Hospital,Danyang,Jiangsu 212300)
出处
《智慧健康》
2024年第9期159-162,共4页
Smart Healthcare
关键词
还原型谷胱甘肽
急诊
常规治疗
心肌钙蛋白
胆碱酯酶
肝功能
Reduced glutathione
Emergency department
Routine treatment
Cardiac calcium protein
Cholinesterase
Liver function
作者简介
谢莉(1986-),女,汉族,江苏丹阳,本科,主治医师,研究方向:急危重症。
