摘要
缺血性心脏病是全球范围内导致死亡的主要病因之一。哺乳动物雷帕霉素靶蛋白(mTOR)是一种调控蛋白质合成、细胞生长、增殖和自噬的丝氨酸/苏氨酸蛋白激酶。近年来研究证实mTOR在缺血性心脏病的发生及发展过程中起重要作用。现就mTOR及其相关信号通路在缺血性心脏病药物研究进展方面进行综述,旨在为临床治疗及药物研发提供新的思路。
Ischemic heart disease is a prominent global cause of mortality.The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis,cell growth,proliferation,and autophagy.Recent research has substantiated the significant role played by mTOR in the pathogenesis and progression of ischemic heart disease.This article provides an overview of the advancements made in understanding mTOR and its associated signaling pathways in relation to ischemic heart disease,aiming to offer novel insights for clinical treatment strategies and drug development.
作者
庞自豪
贾青青
韩博文
张莉
PANG Zihao;JIA Qingqing;HAN Bowen;ZHANG Li(Graduate School of Hebei North University,Zhangjiakou 075000,Hebei,China;Graduate School of Hebei Medical University,Shijiazhuang 050017,Hebei,China;Department of Cardiovascular Medicine,Hebei General Hospital,Shijiazhuang 050051,Hebei,China)
出处
《心血管病学进展》
CAS
2024年第4期326-331,共6页
Advances in Cardiovascular Diseases
基金
河北省卫生厅资助课题(20130006)。
作者简介
通信作者:张莉,E-mail:1136329347@qq.com。
