摘要
目的 探究调中化湿汤对胃癌根治术后患者免疫功能及生活质量的影响。方法 选取100例行胃癌根治术的患者为研究对象,按照随机数字表法将其分为对照组和治疗组,各50例。对照组给予常规西医治疗,治疗组在常规西医治疗基础上给予调中化湿汤治疗。比较两组的治疗效果。结果 治疗后,两组的中医证候积分均降低,卡诺夫斯基健康状况量表(KPS)评分均升高,且治疗组优于对照组(P<0.05)。治疗后,两组的Piper疲乏量表(PFS)各维度评分均低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,两组的生命质量测定量表(FACT-G)各维度评分均高于治疗前,且治疗组高于对照组(P<0.05)。治疗后,两组的CD3^(+)、CD4^(+)、及CD4^(+)/CD8^(+)均升高,CD8^(+)均降低,且治疗组优于对照组(P<0.05)。治疗后,两组的白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及干扰素-γ(IFN-γ)水平均低于治疗前,且治疗组低于对照组(P<0.05)。治疗组的不良反应分级明显优于对照组(P<0.05)。结论 调中化湿汤可改善胃癌根治术后患者的免疫功能,提高生存质量,且安全性较好。
Objective To investigate the effects of Tiaozhong Huashi decoction on immune function and quality of life in patients with gastric cancer after radical operation.Methods A total of 100 patients undergoing gastric cancer radical operation were selected as the research objects and divided into control group and treatment group according to the random number table method,with 50 cases in each group.The control group was given conventional western medicine treatment,and the treatment group was given Tiaozhong Huashi decoction on the basis of conventional western medicine treatment.The therapeutic effects of the two groups were compared.Results After treatment,the TCM syndrome score in two groups decreased,and the Karnofsky Performance Scale(KPS)score increased,and those in the treatment group were better than the control group(P<0.05).After treatment,the scores of each dimension of Piper Fatigue Scale(PFS)in the two groups were lower than those before treatment,and those in the treatment group were lower than the control group(P<0.05).After treatment,the scores of each dimension of Functional Assessment of Cancer Therapy(FACT-G)in the two groups were higher than those before treatment,and those in the treatment group were higher than the control group(P<0.05).After treatment,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in two groups increased,CD8^(+)decreased,and those in the treatment group were better than the control group(P<0.05).After treatment,the levels of interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in the two groups were lower than those before treatment,and those in the treatment group were lower than the control group(P<0.05).The adverse reaction grade in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Tiaozhong Huashi decoction can improve the immune function in patients with gastric cancer after radical operation, improve the quality of life, and has good safety.
作者
李琳婵
杨学芳
谢燕华
鱼麦侠
许鹏
蒋传森
郝梅梅
缑娇
LI Linchan;YANG Xuefang;XIE Yanhua;YU Maixia;XU Peng;JIANG Chuansen;HAO Meimei;GOU Jiao(Oncology Department,Shaanxi Provincal Hospital of Chinese Medicine,Xi'an 710000;Infection Department,the No.2 People's Hospital of Lanzhou,Lanzhou 730000;Surgical Department,Traditional ChineseMedicine Hospital of Zhashui County,Shangluo 711400,China)
出处
《临床医学研究与实践》
2024年第15期113-116,共4页
Clinical Research and Practice
基金
陕西省重点研发计划项目(No.2020SF-348)。
关键词
调中化湿汤
胃癌根治术
免疫功能
生活质量
免疫因子
Tiaozhong Huashi decoction
radical gastrectomy for gastric cancer
immune function
quality of life
immune factor
作者简介
李琳婵(1989-),女,主治医师,硕士。研究方向:恶性肿瘤的防治;通讯作者:蒋传森,E-mail:954520003@qq.com.
