摘要
^(211)At是理想的靶向α治疗核素,^(209)Bi(α,2n)^(211)At是产生该放射性核素的重要核反应,精确可靠的核反应数据对于^(211)At核素生产具有重要意义。^(209)Bi(α,3n)^(210)At反应产物^(210)At核素会衰变为剧毒的^(210)Po核素,掌握该反应信息也有助于安全有效提取^(211)At产物。为获得上述反应相关信息,对国际核反应实验数据库(EXFOR)中相关实验测量数据进行了收集分析,使用EMPIRE程序,基于选取的合理光学模型势与能级密度参数对上述反应的激发函数进行了计算。通过理论计算结果与实验数据的比对,得到了^(209)Bi(α,2n)^(211)At、^(209)Bi(α,3n)^(210)At反应激发函数。在此基础上,计算了^(211)At核素和^(210)At核素的厚靶产额。最后得到了入射能量小于50 MeV能区范围内^(209)Bi(α,2n)^(211)At、^(209)Bi(α,3n)^(210)At反应激发函数推荐值及^(211)At(医用放射性同位素)和^(210)At(衰变子体为长寿命极毒性核素^(210)Po)的厚靶产额推荐评价结果。^(210)At核素厚靶产额计算结果表明,生产^(211)At核素过程中,入射α粒子能量需低于29 MeV。此条件下^(210)At与^(211)At厚靶产额比小于10^(-5),满足国际放射防护委员会规定的职业摄入量,符合^(211)At后续标记的要求。
The excitation function of the charged particle-induced reaction plays an important role in basic nuclear physics research,nuclear engineering design and nuclear technology applications,and which is also essential input information required in areas such as accelerator shielding and fusion reactor design,space radiation effects,radiation therapy and biomedical radioisotope production.In the field of tumor therapy,^(211)At is ideal targeted therapeutic nuclide for generatingα-rays,which is prepared byα-particle bombardment of a bismuth target,and therefore the large-scale production of^(211)At nuclide relies on the information related to the data of^(209)Bi(α,2n)^(211)At reaction excitation function and the thick target yield of the^(211)At nuclide.The production of^(211)At nuclide is accompanied with the production of^(210)At nuclide(the decaying substrates are highly toxic^(210)Po nuclides),and it is also necessary to analyze the data of excitation function for the^(209)Bi(α,3n)^(210)At reaction and the thick target yield of the^(210)At nuclide for determining whether the prepared^(211)At product meets the requirements of the subsequent drug labelling.Based on the above background,the experimental data of^(209)Bi(α,2n)^(211)At and^(209)Bi(α,3n)^(210)At reaction excitation function in the Experimental Nuclear Reaction Database(EXFOR)were compiled and analyzed.However,there are still divergency in the experimental data of the reaction excitation functions,especially for the^(209)Bi(α,3n)^(210)At reaction,and the analyzed available experimental data are discontinuous in some energy region.For providing the reasonable and continuous data of the above two reactions,the relevant theoretical calculations were carried out based on the EMPIRE code.Through the comparison between the experimental data and the EMPIRE calculation results,the reasonable forms of optical potential parameters and level density parameters are chosen.With the enhanced generalized superuid model(EGSM)for level density in the EMPIRE code,the evolution data of the excitation functions of the above two reactions are obtained,and both of them are in general agreement with the analyzed experimental data.Based on the evolution data of^(209)Bi(α,2n)^(211)At reaction excitation function,the thick target yield of the medical radioisotope^(211)At was calculated,and it is in good agreement with the related experimental data.Besides,the thick target yield of^(210)At(the parent nucleus of the highly toxic nuclide^(210)Po)was also studied.And the results show that the thick target yield ratio of^(210)At to^(211)At is less than 10^(-5)at Eα<29.0 MeV,which is lower than the prescribed occupational intake and meets the requirements for^(211)At subsequent labelling.
作者
刘洋阳
黄小龙
王记民
刘丽乐
金永利
王香涵
汪文烨
LIU Yangyang;HUANG Xiaolong;WANG Jimin;LIU Lile;JIN Yongli;WANG Xianghan;WANG Wenye(China Nuclear Data Center,China Institute of Atomic Energy,Beijing 102413,China)
出处
《原子能科学技术》
EI
CAS
CSCD
北大核心
2024年第5期982-989,共8页
Atomic Energy Science and Technology
基金
国家自然科学基金(12205377)。
关键词
带电粒子核反应
数据评价
激发函数
厚靶产额
charged particle-induced reaction
data evolution
excitation function
thick target yield
作者简介
通信作者:刘丽乐。
