摘要
过敏性疾病如过敏性鼻炎(AR)、特应性皮炎(AD)和过敏性哮喘(AS)是由免疫系统紊乱引起的全身性疾病。由于环境污染、气候变化等因素,这些疾病的发病率逐年上升,越来越引起人们的关注。外泌体是机体所有细胞均可释放的一种细胞外囊泡,在细胞之间输送货物,辅助细胞间通信。免疫细胞可释放或利用外泌体来触发、增强或抑制免疫反应,因此外泌体在免疫反应中发挥重要作用,并可通过外泌体相关的免疫疗法缓解患者过敏性疾病的发生发展。本文就不同来源外泌体在常见的AR、AD、AS等过敏性疾病中的致病机制及其潜在治疗作用进行探讨。
Allergic diseases such as allergic rhinitis(AR),atopic dermatitis(AD)and allergic asthma(AS)are systemic diseases caused by disorders of the immune system.The incidence of these diseases is increasing year by year due to factors such as environmental pollution and climate change,which are of increasing concern.Exosomes are extracellular vesicles that can be released by all cells of the body to transport cargos between cells and assist in intercellular communication.Immune cells can release or use exosomes to enhance,deviate or suppress the immune response,thus exosomes play an important role in the immune response and can be used to mitigate the development of allergic diseases in patients through exosome-related immunotherapy.In this paper,the pathogenic mechanisms of exosomes from different sources in common allergic diseases such as AR,AD and AS and their potential therapeutic roles are being reviewed.
作者
徐祖钰
高蓉
邹健
XU Zuyu;GAO Rong;ZOU Jian(Wuxi Medical Center of Nanjing Medical University,Wuxi People's Hospital,Nanjing Medical University,Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi,Jiangsu 214023,China)
出处
《热带医学杂志》
CAS
2024年第3期437-441,共5页
Journal of Tropical Medicine
基金
国家自然科学基金(82172954,82101875)。
作者简介
徐祖钰(1995-),女,硕士研究生,从事临床检验诊断学研究工作;通信作者:邹健,E-mail:zoujan@njmu.edu.cn。
