摘要
目的促进临床抗菌药物的合理使用。方法通过医院信息系统收集并比较医院抗菌药物分层分类管理前后抗菌药物使用相关指标。其中分层管理包括事前个性化、事中实时化、事后目标化三步,分类管理中将科室分为重点科室、次重点科室、一般科室。结果与管理前(2022年1月至6月)比较,管理后(2022年7月至12月)医院抗菌药物使用强度(AUD)由44.27降至38.37,且总体呈下降趋势;用药频度(DDDs)由228302.53降至189493.16,DDDs变化最明显药品为吗啉硝唑氯化钠注射液(降幅为65.50%),头孢菌素类及硝咪唑类药物DDDs下降明显。抗菌药物使用率由38.31%降至36.03%,药占比由12.33%降至10.80%,联用比例由25.20%降至19.46%,抗感染疗程由(7.38±0.05)d缩短至(6.83±0.05)d;患者平均住院日显著缩短,抗菌药物使用金额显著降低,病原学送检率显著升高(P<0.05)。结论加强抗菌药物管理,可提高临床医师对抗菌药物相关技术规范的依从性,促进临床合理使用抗菌药物。
Objective To promote the rational use of antimicrobial drugs in clinical practice.Methods The data related to the application of antimicrobial drugs before and after hierarchical and classified management in the Hospital Information System were collected and compared.Hierarchical management included three steps including first personalized management,middle real-time management and final targeted management.The departments were divided into key departments,sub-key departments and general departments in the classified management.Results Compared with those before management(January to June 2022),the antibiotics use density(AUD)in the hospital decreased from 44.27 to 38.37 after management(July to December 2022),and showed a decreasing trend overally;the defined daily doses(DDDs)decreased from 228302.53 to 189493.16,the drug with the most significant change in DDDs was the Morinidazole and Sodium Chloride Injection with a decrease of 65.50%,and cephalosporins and nitroimidazoles showed a significant decrease in DDDs.Compared with those before management,the usage rate of antimicrobial drugs decreased from 38.31%to 36.03%,the proportion of antimicrobial drugs decreased from 12.33%to 10.80%,the proportion of combined use of antimicrobial drugs decreased from 25.20%to 19.46%,and the duration of anti-infection treatment shortened from(7.38±0.05)d to(6.83±0.05)d.Compared with those before management,the average length of hospital stay of patients significantly shortened,the consumption sum of antimicrobial drugs significantly decreased,and the submission rate of etiological specimens significantly increased(P<0.05).Conclusion Strengthening the antimicrobial stewardship can improve the compliance rate of clinical physicians in the relevant technical specifications and promote the rational use of antimicrobial drugs in clinical practice.
作者
魏鹏翔
梁茂本
印文
WEI Pengxiang;LIANG Maoben;YIN Wen(The Affiliated Huai′an No.1 People′s Hospital of Nanjing Medical University,Huai′an,Jiangsu,China 223300)
出处
《中国药业》
CAS
2024年第10期20-24,共5页
China Pharmaceuticals
关键词
抗菌药物
分层分类管理
合理用药
药学服务
antimicrobial drug
hierarchical and classified management
rational drug use
pharmaceutical care
作者简介
第一作者:魏鹏翔,男,硕士研究生,药师,研究方向为临床药学,(电子信箱)564987948@qq.com;通信作者:印文,女,硕士研究生,助理研究员,研究方向为医院管理,(电子信箱)50292737@qq.com。
