摘要
宫颈癌是常见的女性生殖系统恶性肿瘤之一,尽管临床上已采取各种实验技术手段进行早期宫颈病变的筛查,但宫颈癌的发病率和病死率仍居高不下。C反应蛋白(C-reactive Protein,CRP)是一种正向急性时相反应蛋白,其在机体感染或炎症状态时急剧升高,并在不同类型恶性肿瘤中显示出诊断和预后价值。最新研究表明,CRP可用于宫颈癌预后评估、疗效观察和并发症预测,CRP检测能够帮助识别宫颈癌进展和相关死亡风险增加的患者,其分子机制主要包括CRP对抗肿瘤免疫、促癌基因的表达、化疗耐药等过程的调控,涉及磷脂酰肌醇3-激酶/蛋白激酶B(Phosphoinositol 3-Kinase/Protein Kinase B,PI3K/Akt)、细胞外调节蛋白激酶(Extracellular Signal-Regulated Kinase,ERK)、核转录因子-κB(Nuclear Factor-κB,NF-κB)等众多信号通路。本文则围绕相关研究的最新进展作一综述,并展望了该领域未来的发展方向,有助于指导基于CRP检测的宫颈癌筛查和靶向CRP的宫颈癌治疗新手段。
Cervical cancer is one of the common malignant tumors of the female reproductive system.Although vari⁃ous experimental techniques have been adopted in clinical practice to screen early cervical lesions,the morbidity and mortality of cervical cancer are still high.C-reactive protein(CRP)is a positive acute phase reaction protein,which in⁃creases sharply in the body during infection or inflammation,and shows diagnostic and prognostic value in different types of malignant tumors.Recent studies have shown that CRP can be used to assess cervical cancer prognosis,ob⁃serve efficacy,and predict complications,and that CRP testing can help identify patients at increased risk of cervical cancer progression and associated death.Its molecular mechanism mainly includes the regulation of CRP anti-tumor immunity,oncogene expression,chemotherapy resistance and other processes,involving many signaling pathways such as phosphoinositol 3-kinase/protein kinase B(PI3K/Akt),extracellular signal-regulated kinase(ERK),nuclear factor-κB(NF-κB).This article reviewed the latest progress of relevant research and looks forward to the future development direction of this field,which will help guide the cervical cancer screening based on CRP detection and the new cervical cancer treatment targeting CRP.
作者
宋彬
陈黎
陈晨
SONG Bin;CHEN Li;CHEN Chen(Department of Clinical Laboratory,Zibo Hospital of Traditional Chinese Medicine,Zibo,Shandong Province,255300 China;Department of Clinical Laboratory,Zibo Maternal and Child Health Hospital,Zibo,Shandong Province,255000 China;Department of Medical Genetics,Zibo Maternal and Child Health Hospital,Zibo,Shandong Province,255000 China)
出处
《系统医学》
2024年第5期184-189,共6页
Systems Medicine
关键词
C反应蛋白
宫颈癌
预后
分子机制
C-reactive protein
Cervical cancer
Prognosis
Molecular mechanism
作者简介
宋彬(1980-),男,本科,主管技师,主要从事临床基础和生化学检验与肿瘤的相关性研究工作。
