摘要
艾司氯胺酮是氯胺酮的纯右旋同分异构体,与谷氨酸N-甲基-D-天冬氨酸受体和μ阿片受体亲和力更高,具有更强的镇静、镇痛、抗抑郁等作用,并且起效和消除迅速,抑制呼吸作用弱,可轻微兴奋循环系统,可扩张气管及支气管,不良反应发生率低,在精神疾病领域和临床麻醉应用广泛。本文对其临床应用及不良反应进行综述,以期为艾司氯胺酮在医疗使用中提供借鉴和参考。
Esketamine is the pure enantiomer of racemic ketamine,with higher affinity for N-methyl-D-aspartate(NMDA)receptors and μ-opioid receptors.It possesses stronger sedative,analgesic,and antidepressant effects,with rapid onset and elimination.It has a weak respiratory depressive effect and can mildly stimulate the cardiovascular system.It can also dilate the bronchi and bronchioles.Esketamine has a low incidence of adverse reactions and is widely used in the field of mental illness and clinical anesthesia.This article provides a comprehensive review of its clinical applications and adverse reactions,aiming to provide references and guidance for the medical use of esketamine.
作者
田春林
涂青梅
陈好亮
田刚
TIAN Chunlin;TU Qingmei;CHEN Haoliang(Affiliated Renhe Hospital of China Three Gorges University,Hubei,Yichang 443000,China;不详)
出处
《河北医药》
CAS
2024年第8期1234-1238,共5页
Hebei Medical Journal
基金
湖北省自然科学基金(编号:2014CFC1150)。
关键词
艾司氯胺酮
临床应用
麻醉
抗抑郁
术后认知功能障碍
esketamine
clinical application
anesthesia
antidepressant
postoperative cognitive dysfunction
作者简介
通信作者:田刚,E-mail:76006657@qq.com。
