摘要
目的探讨双水平气道正压通气(BiPAP)无创呼吸机无创呼吸机辅助噻托溴铵治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的临床疗效。方法选取2017年3月至2019年3月丰城市人民医院收治的120例COPD合并呼吸衰竭患者作为研究对象,按照随机数字表法分为对照组与实验组,每组60例。对照组予以BiPAP无创呼吸机治疗,实验组在对照组基础上给予噻托溴铵粉雾剂,比较两组临床疗效、血气分析指标[pH、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、血氧饱和度(SpO_(2))]、肺功能指标[第1秒用力呼气容积(FEV1)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)]、WBC、中性粒细胞百分比(NEU)、C-反应蛋白(CRP)水平。结果实验组治疗总有效率为90.00%,明显高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,两组pH、PaO_(2)、SpO_(2)均高于治疗前,PaCO_(2)均低于治疗前,且实验组pH、PaO_(2)、SpO_(2)均高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。治疗后,两组FEV1、FEV1/FVC均大于治疗前,且实验组大于对照组,差异有统计学意义(P<0.05)。治疗后,两组WBC、NEU、CRP水平均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。结论BiPAP无创呼吸机辅助噻托溴铵治疗COPD合并呼吸衰竭疗效显著,可改善患者肺功能、氧合功能,减轻患者炎症反应,值得临床推广应用。
Objective To investigate the clinical efficacy of biphasic positive airway pressure(BiPAP)noninvasive ventilator assisted tiotropium bromide in the treatment of chronic obstructive pulmonary disease(COPD)with respiratory failure.Methods 120 patients with COPD complicated with respiratory failure admitted to Fengcheng People's Hospital from March 2017 to March 2019 were selected as the research subjects,they were divided into the control group and the experimental group according to the random number table method,,with 60 cases in each group.The control group was treated with BiPAP non-invasive ventilator,and the experimental group was treated with tiotropium bromide powder aerosol on the basis of the control group.The clinical efficacy,blood gas analysis indexes(pH,oxygen partial pressure[PaO_(2)],carbon dioxide partial pressure[PaCO_(2)],blood oxygen saturation[SpO_(2)]),lung function indexes(forced expiratory volume in the first second[FEV1],forced expiratory volume in the first sec-ond/forced vital capacity[FEV1/FVC]),WBC,neutrophil percentage(NEU),C-reactive protein(CRP)levels were compared between the two groups.Results The total treatment effective rate in the experimental group was 90.00%,which was significantly higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the pH,PaO_(2) and SpO_(2) of the two groups were higher than those be-fore treatment,PaCO_(2) was lower than that before treatment,and the pH,PaO_(2) and SpO_(2) in the experimental group were higher than those in the con-trol group,PaCO_(2) was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,FEV1 and FEV1/FVC of the two groups were higher than those before treatment,and the experimental group were higher than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of WBC,NEU and CRP of the two groups were lower than those before treatment,and the experimental group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion BiPAP noninvasive ventilator assisted tiotropium bromide in the treatment of COPD complicated with respiratory failure is effective,which can improve the lung func-tion and oxygenation function of patients and reduce the inflammatory response of patients,and it is worthy of clinical promotion and application.
作者
徐琴
熊闽春
聂璇
XU Qin;XIONG Minchun;NIE Xuan(Department of Respiratory Medicine,Fengcheng People's Hospital,Yichun,Jiangxi,331100,China;Department of Respiratory and Critical Care Medicine,Fengcheng People's Hospital,Yichun,Jiangxi,331100,China)
出处
《当代医学》
2023年第30期34-37,共4页
Contemporary Medicine
关键词
慢性阻塞性肺疾病
呼吸衰竭
噻托溴铵
Chronic obstructive pulmonary disease
Respiratory failure
Tiotropium bromide
