摘要
目的探讨耐药金葡菌引起老年重症肺部感染患者药物治疗中利奈唑胺的效果观察。方法选取109例锦州医科大学附属第一医院重症医学科收治的老年重症肺部感染患者且这些患者的感染均是由耐药金黄色葡萄球菌引起,按照随机数字表法分为对照组和试验组,对照组患者54例给予万古霉素治疗;试验组患者55例给予利奈唑胺治疗,分别观察两组患者临床疗效、金黄色葡萄球菌清除率、炎症细胞水平、肺功能标准及副作用发生率。结果治疗后两组相比,试验组的临床治疗有效率和总细菌清除率比对照组高(P<0.05);试验组TNF-α、IL-1β等炎症因子水平低于对照组,TGF-β水平高于对照组(P<0.05);试验组PEF、FVC、FEV1指标改善效果更优(P<0.05);试验组不良反应发生率更低(P<0.05)。结论耐药金黄色葡萄球菌引起肺部感染的老年重症患者的药物治疗中利奈唑胺的作用效果明显可靠,同时还可积极调整炎症水平、改善肺功能,具有不良反应低、细菌清除率高等优势,值得临床推广应用。
Objective To investigate the effect of linezolid in treatment of severe pulmonary infection caused by drug-resistant Staphylococcus aureus in elderly patients.Methods A total of 109 elderly patients with severe pulmonary infection,all of which were caused by drug-resistant Staphylococcus aureus,were selected from the Intensive Care Department of the First Affiliated Hospital of Jinzhou Medical University and divided into control group and experimental group according to random number table method.54 patients in the control group were given vancomycin treatment.55 patients in the experimental group were treated with linezolid.The clinical efficacy,staphylococcus aureus clearance,inflammatory cell level,lung function standard and side effect rate of the two groups were observed respectively.Results After treatment,the clinical effective rate and total bacterial clearance rate of experimental group were higher than that of control group(P<0.05).The levels of TNF-α,IL-1βand other inflammatory factors in experimental groups were lower than those in control group,and the levels of TGF-βwere higher than those in control group(P<0.05).The improvement of PEF,FVC and FEV1 indexes in experimental group was better(P<0.05).The incidence of adverse reactions was lower in experimental group(P<0.05).Conclusion Linezolid has obvious and reliable effect in the drug treatment of elderly patients with severe pulmonary infection caused by drug-resistant Staphylococcus aureus.At the same time,linezolid can also actively adjust the level of inflammation and improve lung function,and has advantages of low adverse reactions and high bacterial clearance rate,which is worthy of clinical promotion and application.
作者
钟倩
付海燕
Zhong Qian;Fu Haiyan(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000 China)
出处
《锦州医科大学学报》
CAS
2024年第2期62-65,共4页
Journal of Jinzhou Medical University
基金
辽宁省自然科学基金项目,项目编号:2021-MS-328。
关键词
耐甲氧西林
金黄色葡萄球菌
肺部感染
老年
重症
利奈唑胺
肺功能
methicillin-resistant
Staphylococcus aureus
pulmonary infection
elderly
severe
linezolid
lung function
作者简介
钟倩(1987),女,辽宁锦州人,主管护师,硕士学位,主要研究方向为内科护理;通信作者:付海燕(1979),女,辽宁锦州人,副主任医师,博士学位,主要研究方向为急危重症。
