摘要
目的:分析阿托伐他汀联合氯吡格雷对冠心病心绞痛患者血脂、血液流变学及心功能的影响。方法:选取2022年5月—2023年5月阳江市人民医院收治的冠心病心绞痛患者92例为研究对象,随机分为对照组和观察组,各46例。对照组采用阿托伐他汀联合阿司匹林肠溶片治疗,观察组采用阿托伐他汀联合氯吡格雷治疗。比较两组血脂、血液流变学、心功能指标及不良反应发生率。结果:治疗后,两组高密度脂蛋白胆固醇(HDL-C)水平高于治疗前,低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)水平低于治疗前,观察组HDL-C水平高于对照组,LDL-C、TC、TG水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组血红蛋白、平均血细胞比容、血细胞比容、血小板压积水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组左心室舒张末期直径(LVEDD)、左心室收缩末期直径(LVESD)水平低于治疗前,左心室射血分数(LVEF)水平高于治疗前,观察组LVEDD、LVESD水平低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀联合氯吡格雷治疗冠心病心绞痛的效果佳,能改善患者血脂、血液流变学指标,提高心功能,安全性好。
Objective:To analyze the effects of atorvastatin combined with clopidogrel on blood lipids,blood rheology and cardiac function in patients with coronary angina pectoris.Methods:Ninety-two patients with coronary angina pectoris admitted to Yangjiang People's Hospital from May 2022 to May 2023 were selected for the study,and were randomly divided into the control group and the observation group,each with forty-six cases.The control group was treated with atorvastatin combined with aspirin enteric-coated tablets,and the observation group was treated with atorvastatin combined with clopidogrel.The two groups were compared in terms of blood lipids,blood rheology,cardiac function indexes and the incidence of adverse reactions.Results:After treatment,the high-density lipoprotein cholesterol(HDL-C)level of the two groups was higher than that before treatment,and the levels of low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),and triglyceride(TG)were lower than that before treatment,the HDL-C level of the observation group was higher than that of the control group,and the levels of LDL-C,TC,and TG were lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of hemoglobin,mean hematocrit,hematocrit,and platelet compact were lower than those before treatment in the two groups,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)of the two groups were lower than those before treatment,and the level of left ventricular ejection fraction(LVEF)was higher than that before treatment,and the levels of LVEDD and LVESD of the observation group were lower than those of the control group,and the level of LVEF was higher than that of the control group,and the difference was statistically significant(P<0.05);compared the incidence rates of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Atorvastatin combined with clopidogrel is effective in the treatment of coronary angina pectoris,which can improve the patients'blood lipids,blood rheology indexes,improve cardiac function,and has good safety.
作者
袁祥
林何益
Yuan Xiang;Lin Heyi(Yangjiang People's Hospital,Yangjiang 529500,Guangdong Province,China)
出处
《中外医药研究》
2024年第5期72-74,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
