摘要
目的 探析阿托伐他汀钙用于脑梗死后认知功能障碍辅助治疗中的价值。方法 选取江苏省宜兴市第六人民医院于2021年1月—2023年6月收治的80例脑梗死后认知功能障碍患者为对象,按随机数表法分为对照组(n=40,应用氯吡格雷治疗)和研究组(n=40,对照组基础上应用阿托伐他汀钙辅助治疗),对比两组患者临床总有效率、不良反应发生率,神经功能缺损、认知功能、日常生活质量、日常生活能力评分及血脂水平。结果 研究组总有效率(95.00%)较对照组高(80.00%),差异有统计学意义(χ^(2)=4.114,P<0.05)。治疗前,两组神经功能缺损、认知功能、日常生活质量及日常生活能力评分比较,差异无统计学意义(P均>0.05),治疗后,研究组神经功能缺损评分低于对照组,认知功能、日常生活质量及日常生活能力评分均高于对照组,血脂水平(胆固醇、三酰甘油、低密度脂蛋白水平及高密度脂蛋白)均优于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 阿托伐他汀钙辅助用于脑梗死后认知功能障碍的治疗,效果显著。
Objective To explore the value of atorvastatin calcium in the adjuvant treatment of cognitive dysfunction after cerebral infarction.Methods A total of 80 patients with cognitive dysfunction after cerebral infarction from the pharmacy department of Yixing Sixth People's Hospital Jiangsu Province from January 2021 to June 2023 were selected as the study objects.Random number table method was used to divide them into the control group(n=40,clopidogrel treatment) and the study group(n=40,atorvastatin calcium assisted treatment on the basis of control group).The total clinical effective rate,incidence of adverse reactions,neurological impairment,cognitive function,quality of daily life,ability of daily living scores and blood lipid level were compared between the two groups of patients.Results The total effective rate of the study group(95.00%) was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.114,P<0.05).There were no statistically significant differences in the scores of neurological impairment,cognitive function,quality of daily life and ability of daily living between two groups before treatment(all P>0.05).The score of neurological impairment in the study group after treatment was lower than that in control group,the score of cognitive function,quality of daily life and ability of daily living after treatment was higher than those in control group,and blood lipid levels(cholesterol,triglyceride,low density lipoprotein and high density lipoprotein) in the study group were better than those in the control group after treatment,and the difference was statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion Atorvastatin calcium assisted in the treatment of cognitive dysfunction after cerebral infarction can acheive a significant effect.
作者
许佳程
裴琳
XU Jiacheng;PEI Lin(Department of Pharmacy,Yixing Sixth People's Hospital,Yixing,Jiangsu Province,214211 China)
出处
《系统医学》
2024年第4期176-179,共4页
Systems Medicine
关键词
阿托伐他汀钙
脑梗死
认知功能障碍
Atorvastatin calcium
Cerebral infarction
Cognitive dysfunction
作者简介
许佳程(1989-),女,本科,主管药师,研究方向为药学;通信作者:裴琳(1978-),女,本科,副主任药师,研究方向为药学,E-mail:379186393@qq.com。
