摘要
目的:系统评价地黄饮子加减及联合常规西药治疗痴呆的有效性。方法:计算机检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Web of science、Embase数据库中地黄饮子加减及联合常规西药治疗痴呆的随机对照试验,检索时间为各数据库建库至2023年9月。筛选符合纳入标准的文献进行质量评价,提取相应资料,采用RevMan5.3软件进行Meta分析。结果:共纳入文献21篇,1647例患者。Meta分析结果显示,治疗组的临床疗效高于对照组[OR=4.22,95%CI(3.22,5.52),P<0.00001],治疗组改善痴呆的MMSE评分高于对照组[MD=3.88,95%CI(1.98,5.77),P<0.0001],治疗组改善痴呆的HDS评分高于对照组[MD=3.86,95%CI(1.85,5.88),P<0.01],治疗组改善痴呆的ADL评分低于对照组[MD=-2.79,95%CI(-4.56,-1.02),P<0.01]。治疗组痴呆的不良反应发生率未明显低于对照组[OR=0.50,95%CI(0.25,0.99),P=0.05>0.01]。结论:地黄饮子加减及联合常规西药治疗痴呆的总有效率高于单纯常规西药治疗,且可改善简易精神状态检查量表(mini-mental state examination,MMSE)、长谷川痴呆量表(hastgawa dementia scale,HDS)和日常生活能力量表(activity of daily living scale,ADL)评分。本研究存在一定的局限性,仍需多中心、大样本、高质量的研究补充论证。
Objective:To systematically evaluate the clinical efficacy of Dihuang Yinzi plus or minus and conventional western medicine in treating dementia.Methods:Retrieve randomized controlled trial of Dihuang Yinzi plus or minus and conventional western medicine in treating dementia.The literature databases retrieved include CNKI,CBM,Wanfang,VIP,PubMed,Web of Science and Embase database.The retrieval time will be from the beginning of each database’s established until September 2023.The literature that met the inclusion criteria was screened for quality evaluation and relevant data included in the study were imported into RevMan 5.3 software for Meta-analysis.Results:A total of 21 randomized controlled studies were included,with a total sample size of 1647cases.Meta-analysis results showed that:The clinical effect in treatment group was higher than the control group[OR=4.22,95%CI(3.22,5.52),P<0.00001],MMSE score in the treatment group was higher than the control group[MD=3.88,95%CI(1.98,5.77),P<0.0001],HDS score in the treatment group was higher than the control group[MD=3.86,95%CI(1.85,5.88),P<0.01],ADL score in the treatment group was lower than the control group[MD=-2.79,95%CI(-4.56,-1.02),P<0.01].The incidence of adverse reactions in the treatment group was not significantly lower than that in the control group[OR=0.50,95%CI(0.25,0.99),P=0.05>0.01].Conclusion:The total effective rate of Dihuang Yinzi plus or minus and conventional western medicine in treating dementia was higher than treatment of western medicine alone,and it can also improve Mini-mental state examination(MMSE)and Hastgawa dementia scale(HDS)and the Activity of daily living scale(ADL).Due to the limitations of this study,multi-center,large-sample and high-quality studies are still needed to supplement the demonstration.
作者
宋明容
任佳慧
陈军磊
于淼
关慧波
Mingrong SONG;Jiahui REN;Junlei CHEN;Miao YU;Huibo GUAN(Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040,China)
出处
《阿尔茨海默病及相关病杂志》
2024年第2期114-121,共8页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
国家自然科学基金资助项目(81803984)
黑龙江省自然科学基金资助项目(LH2019H052)
黑龙江省中医药科研项目(ZHY2023-042)
2023年黑龙江中医药大学研究生创新科研项目(2023yjscx015)
2022年黑龙江中医药大学大学生科技创新项目(KY2022-04)。
作者简介
第一作者:宋明容,E-mail:songmingrong3718@163.com;通信作者:关慧波,E-mail:gff921@163.com。
